Abstract:
:The Na+-induced release of accumulated Ca2+ from heart mitochondria is inhibited by amiloride, benzamil and several other amiloride analogues. These drugs do not affect uptake or release of Ca2+ mediated by the ruthenium red-sensitive uniporter and their effects, like those of diltiazem and other Ca2+-antagonists, appear to be localized principally at the Na+/Ca2+ antiporter of the mitochondrion. Benzamil inhibits Na+/Ca2+ antiport non-competitively with respect to [Na+] with a Ki of 167 microM. In the presence of 1.5 mM Pi the Ki for benzamil inhibition of this reaction is decreased to 87 microM.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Jurkowitz MS,Altschuld RA,Brierley GP,Cragoe EJ Jrdoi
10.1016/0014-5793(83)80768-6subject
Has Abstractpub_date
1983-10-17 00:00:00pages
262-5issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(83)80768-6journal_volume
162pub_type
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