Inhibition of Na+-dependent Ca2+ efflux from heart mitochondria by amiloride analogues.

Abstract:

:The Na+-induced release of accumulated Ca2+ from heart mitochondria is inhibited by amiloride, benzamil and several other amiloride analogues. These drugs do not affect uptake or release of Ca2+ mediated by the ruthenium red-sensitive uniporter and their effects, like those of diltiazem and other Ca2+-antagonists, appear to be localized principally at the Na+/Ca2+ antiporter of the mitochondrion. Benzamil inhibits Na+/Ca2+ antiport non-competitively with respect to [Na+] with a Ki of 167 microM. In the presence of 1.5 mM Pi the Ki for benzamil inhibition of this reaction is decreased to 87 microM.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Jurkowitz MS,Altschuld RA,Brierley GP,Cragoe EJ Jr

doi

10.1016/0014-5793(83)80768-6

subject

Has Abstract

pub_date

1983-10-17 00:00:00

pages

262-5

issue

2

eissn

0014-5793

issn

1873-3468

pii

0014-5793(83)80768-6

journal_volume

162

pub_type

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