The Saccharomyces cerevisiae OXA1 gene is required for the correct assembly of cytochrome c oxidase and oligomycin-sensitive ATP synthase.


:The nuclear gene OXA1 was first isolated in Saccharomyces cerevisiae and found to be required at a post-translational step in cytochrome c oxidase biogenesis, probably at the level of assembly. Mutations in OXA1 lead to a complete respiratory deficiency. The protein Oxa1p is conserved through evolution and a human homolog has been isolated by functional complementation of a yeast oxa1- mutant. In order to further our understanding of the role of Oxa1p, we have constructed two yeast strains in which the OXA1 open reading frame was almost totally deleted. Cytochrome spectra and enzymatic activity measurements show the absence of heme aa3 and of a cytochrome c oxido-reductase activity and dramatic decrease of the oligomycin sensitive ATPase activity. Analysis of the respiratory complexes in non-denaturing gels reveals that Oxa1p is necessary for the correct assembly of the cytochrome c oxidase and the ATP synthase complex.




FEBS letters


Altamura N,Capitanio N,Bonnefoy N,Papa S,Dujardin G




Has Abstract


1996-03-11 00:00:00














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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Svensson L,Närlid I,Oldberg A

    更新日期:2000-03-24 00:00:00

  • Spectroelectrochemistry of P700 in native photosystem I particles and diethyl ether-treated thylakoid membranes from spinach and Thermosynechococcus elongatus.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Zhang Y,Nakamura A,Kuroiwa Y,Kato Y,Watanabe T

    更新日期:2008-04-02 00:00:00

  • STD and TRNOESY NMR studies for the epitope mapping of the phosphorylation motif of the oncogenic protein beta-catenin recognized by a selective monoclonal antibody.

    abstract::The interaction of the P-beta-Cat(19-44) peptide, a 26 amino acid peptide (K(19)AAVSHWQQQSYLDpSGIHpSGATTTAP(44)) that mimics the phosphorylated beta-Catenin antigen, has been studied with its monoclonal antibody BC-22, by transferred nuclear Overhauser effect NMR spectroscopy (TRNOESY) and saturation transfer differen...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Megy S,Bertho G,Gharbi-Benarous J,Baleux F,Benarous R,Girault JP

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Upadhyay D,Lecuona E,Comellas A,Kamp DW,Sznajder JI

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    pub_type: 杂志文章


    authors: Yu F,Feng J,Harada JN,Chanda SK,Kenney SC,Sun R

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Satrústegui J,Cuezva JM,Machado A

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Engels F,Willems H,Nijkamp FP

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    pub_type: 杂志文章


    authors: Bruening W,Moffett P,Chia S,Heinrich G,Pelletier J

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Bui BT,Florentin D,Fournier F,Ploux O,Méjean A,Marquet A

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Rodríguez-Moreno A,Sihra TS

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    pub_type: 杂志文章


    authors: Samaddar S,Dutta A,Sinharoy S,Paul A,Bhattacharya A,Saha S,Chien KY,Goshe MB,DasGupta M

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Ohguro H

    更新日期:1997-08-25 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Zabłocki K,Bryła J

    更新日期:1989-12-18 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Adamo S,Caporale C,Aguanno S,Lazdins J,Faggioni A,Belli L,Cortesi E,Nervi C,Gastaldi R,Molinaro M

    更新日期:1986-01-20 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Torrence PF,Alster D,Huss S,Gosselin G,Imbach JL

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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Sikdar SK,Zorec R,Brown D,Mason WT

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    journal_title:FEBS letters

    pub_type: 杂志文章,评审


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Picone D,Temussi PA,Marastoni M,Tomatis R,Motta A

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    journal_title:FEBS letters

    pub_type: 杂志文章,评审


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    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Emre Y,Nübel T

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Owen MC,Beresford CH,Carrell RW

    更新日期:1988-04-25 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Newman RH,Leonard K,Crumpton MJ

    更新日期:1991-02-11 00:00:00

  • Synthesis of holo Paracoccus denitrificans cytochrome c550 requires targeting to the periplasm whereas that of holo Hydrogenobacter thermophilus cytochrome c552 does not. Implications for c-type cytochrome biogenesis.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Sambongi Y,Ferguson SJ

    更新日期:1994-02-28 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Ohga Y,Nakanishi M

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Nord M,Gustafsson JA,Lund J

    更新日期:1995-11-06 00:00:00