Abstract:
:Human natural killer (NK) cells possess an arsenal of receptors programmed to regulate the NK cell functions, once encountering a target cell. In general, the activating receptors mediate cytotoxicity when engaged by their tumor specific, stress induced, virally encoded, or rarely, self ligands. Whereas, the inhibitory receptors bind self molecules, mostly MHC class I, presented on all normal and healthy nucleated cells. However, NK cells also possess numerous, highly homologous, pairs of receptors that sometimes even share the same ligands but display divergent functions. In this review we describe the NK cell repertoire of paired receptors and discuss questions regarding their function and mode of action. We focus primarily on the three PVR-binding receptors; the co-stimulatory DNAM1 and CD96 and the inhibitory TIGIT.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Stanietsky N,Mandelboim Odoi
10.1016/j.febslet.2010.08.047subject
Has Abstractpub_date
2010-12-15 00:00:00pages
4895-900issue
24eissn
0014-5793issn
1873-3468pii
S0014-5793(10)00711-8journal_volume
584pub_type
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