Abstract:
:We examined the effect of sodium butyrate on in vitro angiogenesis and cyclooxygenase (COX) expression using primary cultures of human intestinal microvascular endothelial cells (HIMEC). Butyrate inhibited VEGF-induced cellular proliferation, transmigration and tube formation of HIMEC. Butyrate also inhibited COX-2 expression as well as prostaglandin (PG)E2 and PGI2 production, and administration of PGI2 analog partially reversed the effect of butyrate on HIMEC angiogenesis. These results indicate that sodium butyrate inhibits HIMEC angiogenesis through down-regulation of COX-2 expression and PG production, and suggest that anti-angiogenic mechanisms may also be involved in the inhibitory effect of sodium butyrate on tumor growth.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Ogawa H,Rafiee P,Fisher PJ,Johnson NA,Otterson MF,Binion DGdoi
10.1016/s0014-5793(03)01110-4keywords:
subject
Has Abstractpub_date
2003-11-06 00:00:00pages
88-94issue
1-2eissn
0014-5793issn
1873-3468pii
S0014579303011104journal_volume
554pub_type
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