Abstract:
:The herpesvirus life cycle has two distinct phases: latency and lytic replication. The viral immediate early protein replication and transcription activator (RTA) plays a central role in mediating the balance between these two phases. Here, we demonstrate that a B cell terminal differentiation factor X-box binding protein 1 (XBP-1) can effectively initiates Kaposi's sarcoma-associated herpesvirus (KSHV) reactivation by activating the RTA promoter, which results in the induction of other viral lytic transcripts. We also showed splicing of the XBP-1 mRNA which specifically occurs during B cell differentiation is critical in triggering KSHV reactivation. This work demonstrates the integration of KSHV reactivation mechanisms with host cell differentiation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Yu F,Feng J,Harada JN,Chanda SK,Kenney SC,Sun Rdoi
10.1016/j.febslet.2007.06.056subject
Has Abstractpub_date
2007-07-24 00:00:00pages
3485-8issue
18eissn
0014-5793issn
1873-3468pii
S0014-5793(07)00714-4journal_volume
581pub_type
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