Abstract:
:The present one-drug-one-target paradigm in drug discovery has been considered partially responsible for the more-funding-less-drug predicament in modern pharmaceutical industry. To hit the multiple targets implicated in complex diseases, two strategies, based on multicomponent or single-ingredient, are conceivable. Although the latter is more difficult to be fulfilled than the former, the recent progress made in the fight against Alzheimer's disease (AD) has brought us the first light of success of the latter strategy. In this review, both synthetic and natural multipotent agents are described, which hit two or more targets implicated in AD, e.g., acetylcholinesterase, monoamine oxidase, amyloid-beta, tau protein, metal ions and reactive oxygen species. Nevertheless, due to the potential risks in safety, absorbability and pharmacokinetics of synthetic multipotent agents, natural counterparts seem more promising in the future development.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Zhang HYdoi
10.1016/j.febslet.2005.09.006keywords:
subject
Has Abstractpub_date
2005-10-10 00:00:00pages
5260-4issue
24eissn
0014-5793issn
1873-3468pii
S0014-5793(05)01091-4journal_volume
579pub_type
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