Abstract:
:Silver and gold compounds were tested as potential inhibitors of aquaporins of plant- and human origin. Silver as AgNO(3) or silver sulfadiazine inhibited with high potency (EC(50) 1-10 microM) the water permeability of the peribacteroid membrane from soybean (containing Nodulin 26), the water permeability of plasma membrane from roots (containing plasma membrane integral proteins), and the water permeability of human red cells (containing aquaporin 1). Gold as HAuCl(4) was less effective but still inhibited peribacteroid membrane water permeability (EC(50)=10 microM). Silver and gold are more potent inhibitors of aquaporins than the presently widely used mercury containing compounds.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Niemietz CM,Tyerman SDdoi
10.1016/s0014-5793(02)03581-0keywords:
subject
Has Abstractpub_date
2002-11-20 00:00:00pages
443-7issue
3eissn
0014-5793issn
1873-3468pii
S0014579302035810journal_volume
531pub_type
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