Abstract:
:This study was designed to investigate changes in gene expression associated with stage-specific programmed cell death (PCD) in intersegmental muscles (ISMs) of the moth, Manduca sexta. The technique of differential display reverse transcription PCR was applied to compare mRNA levels before and after the onset of PCD in ISMs. Expression of E75B transcription factor was repressed while another factor, betaFTZ-F1, stayed at a very low level. However, gene coding for a translation-initiation factor (eIF1A) was upregulated. Expression of these genes had not been previously reported to be altered in dying ISMs. An ecdysteroid agonist, RH-5849, that prevented PCD in ISMs also blocked these changes.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Löw P,Talián GC,Sass Mdoi
10.1016/j.febslet.2005.07.079keywords:
subject
Has Abstractpub_date
2005-09-12 00:00:00pages
4943-8issue
22eissn
0014-5793issn
1873-3468pii
S0014-5793(05)00947-6journal_volume
579pub_type
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