Abstract:
:Terminal oligopyrimidine (TOP) mRNAs are a group of messengers translationally regulated according to the growth status of the cell. Two hypotheses have been proposed for the mechanism of the regulation: (i) there is a specific translational regulator which can reversibly alter TOP-mRNA structure, (ii) a component of the general translational apparatus can specifically affect the translation of TOP-mRNAs. To verify one of the two hypotheses we induced a partial inhibition of translation initiation in Xenopus cultured cells and analyzed the effect on TOP-mRNA translation. Our results suggest that a specific regulator is necessary to explain the translational control of these of mRNAs.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Loreni F,Amaldi Fdoi
10.1016/s0014-5793(97)01209-xsubject
Has Abstractpub_date
1997-10-27 00:00:00pages
239-42issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(97)01209-Xjournal_volume
416pub_type
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