Abstract:
:Protein glycosylation, which is a key post-translational event, is catalysed by the glycosyltransferase family of enzymes. There is an increasing body of evidence to suggest that these enzymes may themselves be glycosylated, possibly as an autocatalytic event. Using a novel in vitro system, we have investigated the role of enzyme glycosylation in sialyltransferase catalytic activity. The enzyme activity is glycosylation dependent, with the penultimate galactose residue on complex N-linked oligosaccharides playing a pivotal role. These results serve to underline the complexity of the glycosylation process.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Breen KCdoi
10.1016/s0014-5793(02)02626-1keywords:
subject
Has Abstractpub_date
2002-04-24 00:00:00pages
215-8issue
1-3eissn
0014-5793issn
1873-3468pii
S0014579302026261journal_volume
517pub_type
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