Abstract:
:Induction of differentiation in HL-60 and U-937 leukemic cell lines, resulted in 1.5-10-fold increase in 45Ca2+ uptake. The increased 45Ca2+ uptake in the differentiating cells was inhibited by verapamil, cromolyn and amiloride. Elevation in Ca2+ uptake in differentiating cells was also demonstrated using the fluorescent probe, fura-2 acetoxymethyl ester. The increased 45Ca2+ uptake was accompanied by a decrease in ouabain-insensitive and -sensitive 86Rb+ uptake. Furthermore, correlation between the changes in these activities was observed. Modulation of extracellular pH affected differentiation: higher pH increased the extent of differentiation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Rephaeli A,Aviram A,Englender T,Shaklai Mdoi
10.1016/0014-5793(88)80065-6subject
Has Abstractpub_date
1988-08-29 00:00:00pages
401-5issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(88)80065-6journal_volume
236pub_type
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