Abstract:
:Quiescent fibroblasts derived from human fetal lung can be stimulated to reinitiate DNA synthesis by sequential addition of 3 nM IGF-1 and a low concentration (8 pM) of EGF or by continuous exposure to 10% fetal calf serum or 10 ng/ml PDGF. Bradykinin blocks the IGF-1 and EGF-dependent signals without affecting the response to serum or PDGF. It activates protein kinase C and its anti-mitogenic effect is abolished after this kinase has been down-regulated. Bradykinin has no effect on the binding affinity of the EGF receptor whereas phorbol ester induces its 'transmodulation' to low affinity.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Newman EL,Hyldahl L,Larsson O,Engström W,Rees ARdoi
10.1016/0014-5793(89)81459-0subject
Has Abstractpub_date
1989-07-17 00:00:00pages
225-9issue
1-2eissn
0014-5793issn
1873-3468pii
0014-5793(89)81459-0journal_volume
251pub_type
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