Abstract:
:The nuclear factor NF-IL6 had been suggested to be responsible for the IL-6-mediated induction of several acute-phase proteins. To obtain evidence for the involvement of NF-IL6 in the induction of acute-phase proteins, we introduced the NF-IL6 gene and its truncated mutant (delNFIL6) gene into a hepatoma cell line Hep3B. Then, we examined the effect of the overproduced NF-IL6 and delNFIL6 on the expression of haptoglobin, fibrinogen and albumin. As a result, basal production as well as induction of haptoglobin by IL-6 were augmented by the expression of NF-IL6, whereas delNFIL6 blocked the production of haptoglobin, fibrinogen and albumin.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Natsuka S,Isshiki H,Akira S,Kishimoto Tdoi
10.1016/0014-5793(91)81103-fsubject
Has Abstractpub_date
1991-10-07 00:00:00pages
58-62issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(91)81103-Fjournal_volume
291pub_type
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