Abstract:
:In a previous study [(1987) J. Mol. Biol. 194, 663-673], we isolated ten insertion/deletion mutants (indels) of the maltose binding protein for which the maltose binding constant was only a little or not at all affected. In this paper, we have localized these mutations in the recently solved three-dimensional structure. Contrary to the general expectation, most of the insertion/deletion modifications occurred within elements of secondary structure. An analysis of the inserted residues for three indels found within alpha helices allowed an interpretation regarding protein structure accommodation to such modifications.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Betton JM,Martineau P,Saurin W,Hofnung Mdoi
10.1016/0014-5793(93)81409-ssubject
Has Abstractpub_date
1993-06-28 00:00:00pages
34-8issue
1-2eissn
0014-5793issn
1873-3468pii
0014-5793(93)81409-Sjournal_volume
325pub_type
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