Abstract:
:We have examined the properties of intramolecular G-quadruplexes in which the G3 tracts are separated by single base loops. The most stable complex contained 1',2'-dideoxyribose in all three loops, while loops containing T and C were slightly less stable (by about 2 degrees C). Quadruplexes containing loops with single A residues were less stable by 8 degrees C for each T to A substitution. These folded sequences display similar CD spectra, which are consistent with the formation of parallel stranded complexes with double-chain reversal loops. These results demonstrate that loop sequence, and not just length, affects quadruplex stability.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Rachwal PA,Brown T,Fox KRdoi
10.1016/j.febslet.2007.03.040subject
Has Abstractpub_date
2007-04-17 00:00:00pages
1657-60issue
8eissn
0014-5793issn
1873-3468pii
S0014-5793(07)00308-0journal_volume
581pub_type
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