Abstract:
:The adiponectin paralog CORS-26 (collagenous repeat-containing sequence of 26kDa protein) is a member of the C1q/TNF-alpha molecular superfamily. CORS-26 is a secreted protein and baculovirus-produced CORS-26 released in the supernatant of insect cells forms stable trimers. Adiponectin exerts anti-inflammatory effects in LPS-treated monocytic cells and CORS-26 also reduces IL-6 and TNF-alpha secretion but does not increase IL-10. Suppression of NFkappaB signalling may explain the anti-inflammatory actions of CORS-26. Furthermore CORS-26 protein was detected in human monocytic and dendritic cells. The present data demonstrate for the first time that CORS-26 forms trimers, exerts anti-inflammatory properties and that it is expressed in monocytic cells. Therefore CORS-26 may provide a new target for pharmacological drugs in inflammatory diseases like the metabolic syndrome.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Weigert J,Neumeier M,Schäffler A,Fleck M,Schölmerich J,Schütz C,Buechler Cdoi
10.1016/j.febslet.2005.09.022keywords:
subject
Has Abstractpub_date
2005-10-24 00:00:00pages
5565-70issue
25eissn
0014-5793issn
1873-3468pii
S0014-5793(05)01128-2journal_volume
579pub_type
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