Abstract:
:SNI-2011 induces the long-lasting increase in the amount of aquaporin-5 (AQP5) in apical plasma membranes (APMs) of rat parotid acini in a concentration-dependent manner. This induction was inhibited by p-F-HHSiD, U73122, TMB-8, or dantrolene but not by bisindolmaleimide or H-7, indicating that SNI-2011 acting at M(3) muscarinic receptors induced translocation of AQP5 via [Ca(2+)](i) elevation but not via the activation of protein kinase C. In contrast, acetylcholine induced a transient translocation of AQP5 to APMs. SNI-2011 induces long-lasting oscillations of [Ca(2+)](i) in the presence of extracellular Ca(2+). Thus, SNI-2011 induces a long-lasting translocation of AQP5 to APMs coupled with persistent [Ca(2+)](i) oscillations.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Ishikawa Y,Skowronski MT,Ishida Hdoi
10.1016/s0014-5793(00)01763-4keywords:
subject
Has Abstractpub_date
2000-07-21 00:00:00pages
253-7issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(00)01763-4journal_volume
477pub_type
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