Abstract:
:Mitochondria continually fuse and divide to dynamically adapt to changes in metabolism and stress. Mitochondrial dynamics are also required for mitochondrial DNA (mtDNA) integrity; however, the underlying reason is not known. In this study, we examined the link between mitochondrial fusion and mtDNA maintenance in Schizosaccharomyces pombe, which cannot survive without mtDNA, by screening for suppressors of the lethality induced by loss of the dynamin-related large GTPase Msp1p. Our findings reveal that inactivation of Msp1p induces a ROS-dependent nuclear mutator phenotype that affects mitochondrial fission genes involved in suppressing mitochondrial fragmentation and mtDNA depletion. This indicates that mitochondrial fusion is crucial for maintaining the integrity of both mitochondrial and nuclear genetic information. Furthermore, our study suggests that the primary roles of Msp1p are to organize mitochondrial membranes, thus making them competent for fusion, and maintain the integrity of mtDNA.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Delerue T,Khosrobakhsh F,Daloyau M,Emorine LJ,Dedieu A,Herbert CJ,Bonnefoy N,Arnauné-Pelloquin L,Belenguer Pdoi
10.1002/1873-3468.12432subject
Has Abstractpub_date
2016-10-01 00:00:00pages
3544-3558issue
20eissn
0014-5793issn
1873-3468journal_volume
590pub_type
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