Abstract:
:Heme is essential and synthesized via highly regulated processes. For this reason, most organisms strive to recycle it or acquire it from their environment. When heme is bound to proteins noncovalently, degradation of the polypeptide is sufficient to release it. However, in some hemoproteins, such as c-type cytochromes, heme is covalently bound to the protein backbone. We use the heme auxotroph Caenorhabditis elegans to investigate if cytochromes c can be a heme source, and we show that this organism must encode a novel system which specifically cleaves the thioether bonds of c-type cytochromes. We also find that at limiting heme concentrations, while somatic tissues develop normally the germline fails to proliferate, suggesting the presence of a heme-sensing checkpoint in C. elegans.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Murphey AC,Mavridou DAI,Hodgkin J,Ferguson SJdoi
10.1002/1873-3468.13006subject
Has Abstractpub_date
2018-03-01 00:00:00pages
928-938issue
6eissn
0014-5793issn
1873-3468journal_volume
592pub_type
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