Abstract:
:Organ failure induced by endotoxic shock has recently been associated with affected mitochondrial function. In this study, effects of in vivo lipopolysaccharide-challenge on protein patterns of rat liver mitochondria in treated animals versus controls were studied by two-dimensional electrophoresis (differential image gel electrophoresis). Significant upregulation was found for ATP-synthase alpha chain and superoxide dismutase [Mn]. Our data suggest that endotoxic shock mediated changes in the mitochondrial proteome contribute to a compensatory reaction (adaptation to endotoxic shock) rather than to a mechanism of cell damage.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Miller I,Gemeiner M,Gesslbauer B,Kungl A,Piskernik C,Haindl S,Nürnberger S,Bahrami S,Redl H,Kozlov AVdoi
10.1016/j.febslet.2006.01.040keywords:
subject
Has Abstractpub_date
2006-02-20 00:00:00pages
1257-62issue
5eissn
0014-5793issn
1873-3468pii
S0014-5793(06)00079-2journal_volume
580pub_type
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