Abstract:
:Long-chain fatty acid amides are cell-signaling lipids identified in mammals and, recently, in invertebrates, as well. Many details regarding fatty acid amide metabolism remain unclear. Herein, we demonstrate that Drosophila melanogaster is an excellent model system for the study long-chain fatty acid amide metabolism as we have quantified the endogenous levels of N-acylglycines, N-acyldopamines, N-acylethanolamines, and primary fatty acid amides by LC/QTOF-MS. Growth of D. melanogaster on media supplemented with [1-(13)C]-palmitate lead to a family of (13)C-palmitate-labeled fatty acid amides in the fly heads. The [1-(13)C]-palmitate feeding studies provide insight into the biosynthesis of the fatty acid amides.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Jeffries KA,Dempsey DR,Behari AL,Anderson RL,Merkler DJdoi
10.1016/j.febslet.2014.02.051subject
Has Abstractpub_date
2014-05-02 00:00:00pages
1596-602issue
9eissn
0014-5793issn
1873-3468pii
S0014-5793(14)00180-Xjournal_volume
588pub_type
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