Abstract:
:Both acute myeloid leukemia 1 and c-Fos are regulatory factors of hematopoietic cell differentiation. We identified that the c-fos promoter contains an acute myeloid leukemia 1 binding site at nucleotide positions -6-+14. c-fos promoter activity was induced by transient overexpression of acute myeloid leukemia 1 in Jurkat T-cells, but not by that of the short form of acute myeloid leukemia 1-MTG8, a chimeric acute myeloid leukemia 1 protein. In 32Dcl3 myeloid cells, stable overexpression of acute myeloid leukemia 1-MTG8 blocked the c-fos gene transcription and cell differentiation, but that of acute myeloid leukemia did not. These data suggest that acute myeloid leukemia 1 and acute myeloid leukemia 1-MTG8 reciprocally regulate the myeloid cell differentiation, possibly by the way of regulating c-fos gene transcription.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Hwang ES,Hong JH,Bae SC,Ito Y,Lee SKdoi
10.1016/s0014-5793(99)00190-8keywords:
subject
Has Abstractpub_date
1999-03-05 00:00:00pages
86-90issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(99)00190-8journal_volume
446pub_type
杂志文章相关文献
FEBS LETTERS文献大全abstract::Heparin-binding epidermal growth factor-like growth factor (HB-EGF), a potent mitogen and migration factor for vascular smooth muscle cells (SMC), promoted neovascularization in vivo in the rabbit cornea. MRI demonstrated quantitatively the angiogenic effect of HB-EGF when introduced subcutaneously into nude mice. HB-...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(98)00283-x
更新日期:1998-04-03 00:00:00
abstract::500 MHz 1H NMR studies of human epidermal growth factor are described. The backbone resonances of the 1-48 derivative of hEGF have been assigned using two-dimensional techniques. Analysis of the type and magnitude of the observed sequential nuclear Overhauser effects and the NH-alpha CH spin-spin coupling constants al...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(86)80869-9
更新日期:1986-09-01 00:00:00
abstract::It is known that the DNA binding Runt domain of the AML1/Runx1 transcription factor coordinates Cl(-) ions. In this paper we have determined Cl(-) binding affinities of AML1 by (35)Cl nuclear magnetic resonance (NMR) linewidth analysis. The Runt domain binds Cl(-) with a dissociation constant (K(d,Cl)) of 34 mM. If CB...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(00)02390-5
更新日期:2001-01-12 00:00:00
abstract::We have used a gene replacement strategy to delete the previously isolated gene [(1987) EMBO J. 6, 2825-2833] for the cytochrome c oxidase subunit I from Paracoccus denitrificans. The resulting mutant was still able to synthesize active cytochrome c oxidase. This led us to look for another locus which could completely...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(90)80609-m
更新日期:1990-02-26 00:00:00
abstract::The number of proteins found in body fluids and at cell surfaces, which are known to display carbohydrate-binding properties, continues to increase rapidly. In these proteins, in addition to a domain associated with lectin properties, one or more, non-lectin domains are present. It is possible that binding of sugar re...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1016/0014-5793(89)80689-1
更新日期:1989-06-19 00:00:00
abstract::To better understand the outcome of the interaction between TNF-related apoptosis-inducing factor (TRAIL) and tumor cells, we studied TRAIL-resistant melanoma cells resulting from prolonged exposure to TRAIL and found that they had higher proliferative activity than the parental cells both in vitro and in vivo. This w...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2005.02.041
更新日期:2005-03-28 00:00:00
abstract::The article presents the results of the first regular study of Russian populations by sequencing the control region of mitochondrial DNA (mtDNA). The sequenced region is the most variable on mtDNA molecule and is commonly used for population and evolutionary studies. Russians form one of the largest ethnic groups (mor...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(99)00115-5
更新日期:1999-02-19 00:00:00
abstract::The site-specific recombination system of bacteriophage P1 is composed of the Cre recombinase that recognizes a 34-bp loxP site. The Cre/loxP system has been extensively used to manipulate eukaryotic genomes for functional genomic investigations. The creation of additional heterologous loxP sequences potentially expan...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(01)02541-8
更新日期:2001-06-15 00:00:00
abstract::Glycogen storage diseases type 1 (GSD 1) are a group of autosomal recessive disorders characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. Mutations of the glucose-6-phosphatase gene are responsible for the most frequent form of GSD 1, the subtype 1a, while mutations of the glucose-6-ph...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(99)01248-x
更新日期:1999-10-08 00:00:00
abstract::Cellular retinoic acid binding proteins (CRABPs) bind all-trans-retinoic acid (atRA) tightly. This study aimed to determine whether atRA is channeled directly to cytochrome P450 (CYP) CYP26B1 by CRABPs, and whether CRABPs interact directly with CYP26B1. atRA bound to CRABPs (holo-CRABP) was efficiently metabolized by ...
journal_title:FEBS letters
pub_type: 信件
doi:10.1002/1873-3468.12303
更新日期:2016-08-01 00:00:00
abstract::Treatment of human vascular smooth muscle cells (SMC) with human alpha-thrombin greatly increased DNA synthesis and cell proliferation. Both the integrity of the catalytic site and that of the anion binding exosite were required for expression of this activity. Experiments employing Northerns indicated induction of c-...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(92)80961-f
更新日期:1992-12-14 00:00:00
abstract::Random sequences of 120-130 amino acid residues were inserted into a surface loop region of Escherichia coli RNase HI. This library was screened and about 10% of the clones were found to retain RNase H activity. Subsequent random mutagenesis led to an increase in RNase H activity and solubility of the protein. The ins...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(96)01522-0
更新日期:1997-02-03 00:00:00
abstract::Galectin-3 is a galactose-specific lectin which has been shown to be involved in several biological functions such as cell growth regulation, cell aggregation and cell differentiation. The partial cloning of the human genomic sequences reveals the presence of a 651 bp intron, 18 bp downstream of the translation initia...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(95)00310-6
更新日期:1995-04-17 00:00:00
abstract::A novel protein that binds specifically to the intracellular domain of the p55 tumor necrosis factor (TNF) receptor was cloned by two-hybrid screening of a HeLa cell cDNA library. Data bank searches revealed high sequence similarity of the protein (55.11) to yeast, nematode and plant proteins, whose functions are yet ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(95)00534-g
更新日期:1995-06-19 00:00:00
abstract::A large protein complex (approx. 2000 kDa) was found in the cytosol of the hyperthermophilic archaebacterium Staphylothermus marinus. The purified protein was shown to be a homomultimer of 93 kDa subunits, the primary structure of which was determined by nucleotide sequence analysis. The protein belongs to the family ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(94)01304-7
更新日期:1994-12-19 00:00:00
abstract::Clusters of codons pairing to low-abundance tRNAs synchronize the translation with co-translational folding of single domains in multidomain proteins. Although proven with some examples, the impact of the ribosomal speed on the folding and solubility on a global, cell-wide level remains elusive. Here we show that upre...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2012.07.012
更新日期:2012-09-21 00:00:00
abstract::Monocyte chemoattractant protein-1 (MCP-1) is a member of the beta chemokine family which acts through specific seven transmembrane receptors to recruit monocytes, basophils, and T lymphocytes to sites of inflammation. To identify regions of the human MCP-1 protein which are important for its biological activity, we h...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(98)00637-1
更新日期:1998-07-03 00:00:00
abstract::A steady-state framework was applied to the ubiquitous tricyclic enzyme cascade structure, as seen in the mitogen-activated protein (MAP) kinase system, to analyze the effect of upstream kinase concentrations on final output response. The results suggest that signal amplification achieved by the cascade structure ensu...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/S0014-5793(04)00021-3
更新日期:2004-01-30 00:00:00
abstract::Human CBS1 is a methionine sulfoxide reductase of type B (MSRB) as it specifically reduced Met-R-SO in peptides with dithiothreitol or the thioredoxin system as reductants. Mutation C169S in the active site completely abolished enzymatic activity, while mutation W110A only reduced activity and C105S had no effect. Lik...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(02)03171-x
更新日期:2002-09-11 00:00:00
abstract::The expression of myf-5, a key component of myogenic regulatory genes, declines progressively in mature somitic cells during vertebrate myogenesis. Little is known about how this down-regulation takes place. Here we provide evidence that an interferon regulatory factor binding element (IRF element) within the Xenopus ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(01)02688-6
更新日期:2001-09-07 00:00:00
abstract::The hyperthermophilic archaeon Sulfolobus solfataricus metabolises glucose and galactose by a 'promiscuous' non-phosphorylative variant of the Entner-Doudoroff pathway, in which a series of enzymes have sufficient substrate promiscuity to permit the metabolism of both sugars. Recently, it has been proposed that the pa...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2005.11.028
更新日期:2005-12-19 00:00:00
abstract::Gangliosides and neutral glycolipids of muscles from normal and dystrophic chickens were studied. Total glycolipid content of the degenerating muscles was higher than the normal muscles. In addition, the myopathic muscles contained a ganglioside which was absent in the unaffected muscles from normal and dystrophic chi...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(82)80768-0
更新日期:1982-12-27 00:00:00
abstract::Replacements of Asp-295 by Asn (D295N) and Glu (D295E) decreased the catalytic center activity of Leuconostoc mesenteroides sucrose phosphorylase to about 0.01% of the wild-type level (k(cat)=200s(-1)). Glucosylation and deglucosylation steps of D295N were affected uniformly, approximately 10(4.3)-fold, and independen...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2007.02.060
更新日期:2007-04-03 00:00:00
abstract::Hydrolysis of GTP, bound to members of the G-protein superfamily, terminates their downstream signaling activity. A conserved glutamine serves a critical role in this pivotal guanosine triphosphatase (GTPase) reaction. However, the role of the catalytic glutamine in GTP hydrolysis is still not well understood. We have...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(98)00930-2
更新日期:1998-08-21 00:00:00
abstract::The intermediate in the reaction catalyzed by 4-chlorobenzoate dehalogenase from Pseudomonas sp. CBS3 was identified as 4-chlorobenzoyl-CoA. One component of 4-chlorobenzoate dehalogenase worked as a a 4-chlorobenzoyl-CoA ligase catalyzing the formation of 4-chlorobenzoyl-CoA from 4-chlorobenzoate, coenzyme A and ATP....
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(91)81265-a
更新日期:1991-09-23 00:00:00
abstract::Cystatins A and C were both shown to inhibit cathepsin B by a two-step mechanism, involving an initial weak interaction followed by a conformational change. Disruption of the major salt bridge anchoring the occluding loop of cathepsin B to the main body of the enzyme by mutation of His110 to Ala converted the binding ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(00)02337-1
更新日期:2000-12-29 00:00:00
abstract::Regulatory protein kinases are involved in various cellular processes such as proliferation, differentiation, and apoptosis. Using cDNA differential display, we identified MOK, a member of the mitogen-activated protein kinase superfamily, as one of the genes induced by a caudal-related homeobox transcription factor, C...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/j.febslet.2004.07.070
更新日期:2004-08-27 00:00:00
abstract::In this study, we investigated enzymatic deglycosylation of glucoamylase from Aspergillus awamori X 100/D27, a glycoprotein which has two N-linked and about forty short mannose-bearing O-linked sugars per molecule. O-Linked sugars were modified by treatment with alpha-mannosidase and N-linked sugars were removed using...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(93)81206-f
更新日期:1993-01-25 00:00:00
abstract::Although neurokinin A (NKA), a tachykinin peptide with sequence homology to substance P (SP), is a weak competitor of radiolabeled SP binding to the NK-1 receptor (NK-1R), more recent direct binding studies using radiolabeled NKA have demonstrated an unexpected high-affinity interaction with this receptor. To document...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/s0014-5793(00)02228-6
更新日期:2000-12-01 00:00:00
abstract::According to the endosymbiont hypothesis, mitochondria are descended from ancient aerobic bacteria that were engulfed by protoeukaryotic cells. Experiments described here show that a synthetic peptide corresponding to a yeast mitochondrial targeting sequence can be imported into Paracoccus denitrificans, a soil bacter...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1016/0014-5793(94)80619-5
更新日期:1994-01-03 00:00:00