Abstract:
:To better understand the outcome of the interaction between TNF-related apoptosis-inducing factor (TRAIL) and tumor cells, we studied TRAIL-resistant melanoma cells resulting from prolonged exposure to TRAIL and found that they had higher proliferative activity than the parental cells both in vitro and in vivo. This was associated with reduced p53 and p21 expression and increased activation of Erk1/2 and Akt. Accelerated proliferation was not due to TRAIL-mediated signaling but appeared to be the result of selection of previously existing, characteristically distinct cells. Moreover, responses of p53 to stimulation in the TRAIL-resistant cells appeared to be impaired.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Wu JJ,Zhang XD,Gillespie S,Hersey Pdoi
10.1016/j.febslet.2005.02.041keywords:
subject
Has Abstractpub_date
2005-03-28 00:00:00pages
1940-4issue
9eissn
0014-5793issn
1873-3468pii
S0014-5793(05)00250-4journal_volume
579pub_type
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