Abstract:
:Gangliosides and neutral glycolipids of muscles from normal and dystrophic chickens were studied. Total glycolipid content of the degenerating muscles was higher than the normal muscles. In addition, the myopathic muscles contained a ganglioside which was absent in the unaffected muscles from normal and dystrophic chickens. Based on the thin-layer chromatographic mobility, treatment with neuraminidases from Vibrio cholerae and Arthrobacter ureafaciens, and reactivity of the asialo-derivative towards anti-ganglio-N-triaosylceramide antibody, the dystrophic-specific ganglioside was tentatively identified as GM2. Data obtained from young and old dystrophic chickens suggested a direct relationship of this ganglioside to muscular dystrophy.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kundu SK,Misra LK,Luthra MGdoi
10.1016/0014-5793(82)80768-0subject
Has Abstractpub_date
1982-12-27 00:00:00pages
359-64issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(82)80768-0journal_volume
150pub_type
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