Abstract:
:Local bending propensity and curvature of DNA can be characterized using a vector description of DNA bendability, based on a set of parameters derived from deoxyribonuclease I (DNase I) cleavage experiments. Two characteristics-arithmetic and vector averages of bendability-were successfully used to predict experimentally known bendable, rigid and curved segments in DNA. A characteristic distribution of bendability is conserved in evolutionarily related kinetoplast sequences. An analysis of the M. genitalium and H. influenzae genomes as well as fragments of human and yeast genomes shows, on the other hand, that highly curved segments--similar to artificially designed curved oligonucleotides--are extremely rare in natural DNA.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Gabrielian A,Simoncsits A,Pongor Sdoi
10.1016/0014-5793(96)00837-xsubject
Has Abstractpub_date
1996-09-09 00:00:00pages
124-30issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(96)00837-Xjournal_volume
393pub_type
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