Abstract:
:We have reported that histone deacetylase (HDAC) inhibitors activate a member of the INK4 family, the p19INK4d gene, causing G1 phase arrest. We report here that HDAC inhibitor, Trichostatin A, activates another member of the INK4 family, the p18INK4c gene, through its promoter in Jurkat cells. Interestingly, the activation patterns of the p18INK4c gene were different from those of p19INK4d. Furthermore, mouse embryo fibroblasts lacking p18Ink4c or p18Ink4c/p19Ink4d were resistant to the growth inhibitory effects of TSA as compared to their wild-type counterpart. Our findings suggest that p18INK4c is involved in TSA-mediated cell growth inhibition and cooperates with p19INK4d.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Yokota T,Matsuzaki Y,Sakai Tdoi
10.1016/j.febslet.2004.08.025keywords:
subject
Has Abstractpub_date
2004-09-10 00:00:00pages
171-5issue
1-3eissn
0014-5793issn
1873-3468pii
S001457930401021Xjournal_volume
574pub_type
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