The complete primary structure of GTP:AMP phosphotransferase from beef heart mitochondria.

abstract：:Incubation of isolated hepatocytes containing normal Ca2+ levels with angiotensin II, vasopressin or A23187 caused significant inhibition of the cAMP response to glucagon. Angiotensin II also inhibited cAMP accumulation induced by either glucagon or epinephrine in Ca2+-depleted hepatocytes. When submaximal doses of ho...

journal_title：FEBS letters

authors： Morgan NG,Exton JH,Blackmore PF

更新日期：1983-03-07 00:00:00

abstract：:Gene expression is controlled through a complex interplay among mRNAs, non-coding RNAs and RNA-binding proteins (RBPs), which all assemble along with other RNA-associated factors in dynamic and functional ribonucleoprotein complexes (RNPs). To date, our understanding of RBPs is largely limited to proteins with known o...

journal_title：FEBS letters

authors： Faoro C,Ataide SF

更新日期：2014-10-16 00:00:00

abstract：:We reported the preparation of a novel trehalose derivative based on enzymatic oxidation of trehalose by water-soluble glucose-3-dehydrogenase (G3DH) from marine bacterium Halomonas sp. alpha-15 cells. The product of G3DH enzymatic conversion was 3,3'-diketotrehalose (3,3'dkT), a novel trehalose derivative of which bo...

journal_title：FEBS letters

authors： Sode K,Akaike E,Sugiura H,Tsugawa W

更新日期：2001-01-26 00:00:00

abstract：:Previous electrophysiological experiments characterized the Sec61 complex, which provides the aqueous path for entry of newly-synthesized polypeptides into the mammalian endoplasmic reticulum, as a highly dynamic channel that, once activated by precursor proteins, fluctuates between main open states with mean conducta...

journal_title：FEBS letters

authors： Erdmann F,Jung M,Eyrisch S,Lang S,Helms V,Wagner R,Zimmermann R

更新日期：2009-07-21 00:00:00

abstract：:Parasitic helminths remain major pathogens of both humans and animals throughout the world. The success of helminth infections depends on the capacity of the parasite to counteract host immune responses but also to exploit host-derived signal molecules for its development. Recent progress has been made in the characte...

journal_title：FEBS letters

authors： Dissous C,Khayath N,Vicogne J,Capron M

更新日期：2006-05-22 00:00:00

abstract：:A mathematical model was developed to estimate flux control coefficients (Co) from titration studies with specific non-competitive inhibitors. In contrast to the normally used graphical determination the model pays regard to the dissociation equilibrium (KD) that exists between inhibitor and its binding sites (Eo) as ...

journal_title：FEBS letters

authors： Gellerich FN,Kunz WS,Bohnensack R

更新日期：1990-11-12 00:00:00

abstract：:EVH1 (enabled VASP (vasodilator-stimulated protein) homology 1)/WH1 (WASP (Wiskott-Aldrich syndrome protein) homology 1) domains, present in Ena VASP and WASP, are protein interaction modules specialised in binding proline-rich ligands. An EVH1/WH1 domain is here identified in the recently cloned SMIF protein, a key p...

journal_title：FEBS letters

authors： Callebaut I

更新日期：2002-05-22 00:00:00

abstract：:Activation of T lymphocytes results in an increase in intracellular Ca2+ due in large part to influx of extracellular Ca2+. Using the patch clamp technique, an inward current in Jurkat T lymphocytes was observed upon depolarization from a holding potential of -90 mV but not from -60 mV. This whole-cell current was ins...

journal_title：FEBS letters

authors： Densmore JJ,Szabo G,Gray LS

更新日期：1992-11-09 00:00:00

abstract：:Male germ cell Rac GTPase-activating protein (MgcRacGAP) is a core regulator of cytokinesis. Furthermore, it appears to be involved in human oncogenesis through cytokinesis-independent mechanisms and has been reported to be essential for nuclear translocation of signal transducer and activator of transcription (STAT) ...

journal_title：FEBS letters

authors： van Adrichem AJ,Wennerberg K

更新日期：2015-12-21 00:00:00

abstract：:A novel gene named fad104 (factor for adipocyte differentiation-104), whose expression level quickly increased in the early stage of adipogenesis, was isolated and characterized. The deduced amino acid sequence of fad104 revealed the possible presence of a fibronectin type III domain and transmembrane domain. The expr...

journal_title：FEBS letters

authors： Tominaga K,Kondo C,Johmura Y,Nishizuka M,Imagawa M

更新日期：2004-11-05 00:00:00

abstract：:When isolated reaction centres of photosystem II are subjected to photoinhibitory illumination, a 41 kDa SDS-PAGE band is observed under all experimental conditions. The same band is also found, together with lower molecular weight fragments of the D1 protein, in whole thylakoids and in all PSII sub-particles investig...

journal_title：FEBS letters

authors： Barbato R,Friso G,Rigoni F,Frizzo A,Giacometti GM

更新日期：1992-09-07 00:00:00

abstract：:The autocrine motility factor (AMF) is a multifunctional protein that is involved in tumor progression including enhanced invasiveness via induction of matrix metalloproteinase-3 (MMP3). The increase in MMP3 was found in an AMF-high production tumor cell line, and c-Jun, c-Fos and mitogen-activated protein kinases (MA...

journal_title：FEBS letters

authors： Haga A,Funasaka T,Deyashiki Y,Raz A

更新日期：2008-06-11 00:00:00

abstract：:Phosphorylcholine (PC) is a classical ligand of C-reactive protein (CRP), a clinically important acute phase protein. In search of new ligands, CRPs were affinity-purified from several pathological samples, which exhibited distinct molecular variants induced in different diseases. Both glycosylated and non-glycosylate...

journal_title：FEBS letters

authors： Das T,Mandal C,Mandal C

更新日期：2004-10-08 00:00:00

abstract：:Suppressors of cytokine signaling (SOCS) proteins possess common structures, a SOCS box at the C-terminus and a SH2 domain at their center. These suppressors are inducible in response to cytokines and act as negative regulators of cytokine signaling. The ASB proteins also contain the SOCS box and the ankyrin repeat se...

journal_title：FEBS letters

authors： Kohroki J,Fujita S,Itoh N,Yamada Y,Imai H,Yumoto N,Nakanishi T,Tanaka K

更新日期：2001-09-14 00:00:00

abstract：:A new inositol derivative could be isolated from the Archaeum Pyrococcus woesei and identified as di-myo-inositol-1,1'-phosphate by 1H, 31P NMR spectroscopy, mass spectrometry and thin layer chromatography. In P. woesei, this inositol phosphate represents the dominant counterion of K+ which ranges from 500 to 600 mM. ...

journal_title：FEBS letters

authors： Scholz S,Sonnenbichler J,Schäfer W,Hensel R

更新日期：1992-07-20 00:00:00

abstract：:The minimal functional enzyme unit of Na,K-ATPase consists of an alpha-beta complex. The alpha-subunit bears all functional domains of the enzyme and so far a regulatory role for the beta-subunit in the catalytic cycle has not been established. On the other hand, increasing experimental evidence suggests that the beta...

journal_title：FEBS letters

authors： Geering K

更新日期：1991-07-22 00:00:00

abstract：:Internal promoters of some genes transcribed by RNA polymerase III (e.g. tRNA genes, adenovirus VA1 RNA gene, human retroposons of the Alu family) contain a conserved sequence element, B-box, interacting with basal transcription factor TFIIIC2 which initiates assembly of the full transcription complex on the genes, an...

journal_title：FEBS letters

authors： Kropotov AV,Tomilin NV

更新日期：1996-05-13 00:00:00

abstract：:Inducible nitric oxide (NO) synthase (iNOS) appears to be a marker of tumor progression in colon carcinogenesis. Here we investigated effects of NO on selected chemokines that differentially regulate angiogenesis, namely pro-angiogenic interleukin (IL)-8 as well as tumor-suppressive interferon-inducible protein-10 (IP...

journal_title：FEBS letters

authors： Hellmuth M,Paulukat J,Ninic R,Pfeilschifter J,Mühl H

更新日期：2004-04-09 00:00:00

abstract：:T cells express two different types of voltage-independent Ca(2+)-activated K(+) channels with small (SK) and intermediate (IK) conductance that serve important roles in the activation of T lymphocytes. In contrast to the IK channels from T lymphocytes which are upregulated upon mitogen stimulation, SK channels of Jur...

journal_title：FEBS letters

authors： Jäger H,Adelman JP,Grissmer S

更新日期：2000-03-10 00:00:00

abstract：:The effect of the myotoxic drug chlorpromazine was studied in vitro on proteins of sarcoplasmic reticulum and mitochondrial matrix of skeletal muscle in the normal mouse. Our results indicate that the drug is specific for calcium-binding proteins (calcium ATPase, calsequestrin and calmitine). Its proteolytic effect on...

journal_title：FEBS letters

authors： Lucas-Heron B,Le Ray B,Schmitt N

更新日期：1995-11-06 00:00:00

abstract：:SSTR3, a somatostatin (SST) receptor, is an adenylyl cyclase (AC)-inhibiting receptor. To assign the G-protein alpha-subunit (G alpha) linked to this receptor, we created a novel reporter system which utilizes the well-established facts that the C-terminal 5 residues of G alpha are the receptor contact site and G alph...

journal_title：FEBS letters

authors： Komatsuzaki K,Murayama Y,Giambarella U,Ogata E,Seino S,Nishimoto I

更新日期：1997-04-07 00:00:00

abstract：:In this paper we introduce monobromobimane, a thiol reagent, as a selective blocker of the recently identified dithiol whose oxidation-reduction status modifies voltage sensing by the mitochondrial permeability transition pore, a cyclosporin A-sensitive channel. Monobromobimane does not inhibit the phosphate carrier, ...

journal_title：FEBS letters

authors： Costantini P,Chernyak BV,Petronilli V,Bernardi P

更新日期：1995-04-03 00:00:00

abstract：:Although signal transducer and activator of transcription 1 (STAT1) mediated regulation of p53 transcription and apoptosis has been previously reported, modulation of other members of the p53 family of transcription factors remains poorly understood. In this study, we found that STAT1 and TA-p73 can interact directly ...

journal_title：FEBS letters

authors： Soond SM,Carroll C,Townsend PA,Sayan E,Melino G,Behrmann I,Knight RA,Latchman DS,Stephanou A

更新日期：2007-03-20 00:00:00

abstract：:Dimethylsulphoxide (DMSO) reductase from R. capsulatus contains a molybdenum-pterin cofactor at its active site. As prepared the molybdenum is in the 6+ oxidation state, devoid of EPR signals. Stepwise reduction generates an EPR signal characteristic of Mo(V) having hyperfine coupling to a single proton and integratin...

journal_title：FEBS letters

authors： Benson N,Farrar JA,McEwan AG,Thomson AJ

更新日期：1992-07-28 00:00:00

abstract：:Proteolytic processing is an important post-translational modification affecting protein activity and stability. In the current study, we investigate the N-terminal cleavage of Trop2, a protein which is overexpressed in many cancers. We demonstrate that Trop2 is cleaved at Arg87 by a transmembrane serine protease, mat...

journal_title：FEBS letters

authors： Kamble PR,Rane S,Breed AA,Joseph S,Mahale SD,Pathak BR

更新日期：2020-10-01 00:00:00

abstract：:Gene conservation, duplication and constitutive expression are intricately linked and strong predictors of essentiality. Here, we introduce metrics based on diversity indices to measure gene conservation, duplication and constitutive expression and validate them by measuring their performance in prediction of essentia...

journal_title：FEBS letters

authors： Arun PV,Miryala SK,Chattopadhyay S,Thiyyagura K,Bawa P,Bhattacharjee M,Yellaboina S

更新日期：2016-05-01 00:00:00

abstract：:Calcium release from internal stores of Entamoeba histolytica, a parasitic protozoan, was observed by measuring fluorescence of Fura-2. Emptying of inositol(1,4,5)trisphosphate (Ins(1,4,5)P3)-sensitive calcium pools in permeabilized E. histolytica did not significantly affect subsequent calcium release by inositol(1,3...

journal_title：FEBS letters

authors： Raha S,Giri B,Bhattacharyya B,Biswas BB

更新日期：1995-04-10 00:00:00

abstract：:The NAD-dependent glycerol-3-phosphate dehydrogenase (glycerol-3-phosphate:NAD+ oxidoreductase; EC 1.1.1.8; G3P DHG) was purified 178-fold to homogeneity from Saccharomyces cerevisiae strain H44-3D by affinity- and ion-exchange chromatography. SDS-PAGE indicated that the enzyme had a molecular mass of approximately 42...

journal_title：FEBS letters

authors： Albertyn J,van Tonder A,Prior BA

更新日期：1992-08-17 00:00:00

abstract：:We report for the first time the identification of 25 microRNAs from tissues originating from chicken embryo and adult chicken. Most of the cloned microRNAs are expressed in both adult chickens and chicken embryos. Fourteen were identified without any prior prediction. One microRNA, miR-757, is thought to be chicken-s...

journal_title：FEBS letters

authors： Xu H,Wang X,Du Z,Li N

更新日期：2006-06-26 00:00:00

abstract：:Mechanisms involved in cell volume regulation are important in SS, SC cells as they might be involved in determining the extent of sickling and the generation of dense cells and irreversibly sickled cells. We have studied in these cells the response to cell swelling of the K+,Cl- transporter. We found that Hb SS, SC a...

journal_title：FEBS letters

authors： Canessa M,Spalvins A,Nagel RL

更新日期：1986-05-05 00:00:00