Abstract:
:The autocrine motility factor (AMF) is a multifunctional protein that is involved in tumor progression including enhanced invasiveness via induction of matrix metalloproteinase-3 (MMP3). The increase in MMP3 was found in an AMF-high production tumor cell line, and c-Jun, c-Fos and mitogen-activated protein kinases (MAPKs) were also highly phosphorylated compared with the parent line. AMF stimulation induced the rapid phosphorylation of the cellular MAPK cascade and MMP3 secretion, which was blocked using a specific MAPK inhibitor. Results of this study suggest that AMF stimulation stimulates MMP3 expression via a MAPK signaling pathway.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Haga A,Funasaka T,Deyashiki Y,Raz Adoi
10.1016/j.febslet.2008.05.005subject
Has Abstractpub_date
2008-06-11 00:00:00pages
1877-82issue
13eissn
0014-5793issn
1873-3468pii
S0014-5793(08)00402-Xjournal_volume
582pub_type
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