Abstract:
:Human D-type prostanoid (DP) and E-type prostanoid 2 (EP2) receptors are regarded as the most closely related receptors among prostanoid receptors. Although these receptors are generated by tandem duplication, their physiological outputs often oppose one another. In the present study, we extracted mutations occurring in the coding regions of both receptors using the 1000 genome project database and found that EP2 receptors have 8-fold fewer amino acid mutations. We speculate that EP2 receptors exhibit more constraints to mutations than DP receptors.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Tanimoto J,Fujino H,Takahashi H,Murayama Tdoi
10.1016/j.febslet.2015.02.006subject
Has Abstractpub_date
2015-03-12 00:00:00pages
766-72issue
6eissn
0014-5793issn
1873-3468pii
S0014-5793(15)00086-1journal_volume
589pub_type
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