Abstract:
:Cellular memory is a ubiquitous phenomenon in cell biology. Using numerical simulation and theoretical analysis, we explored the robustness of cellular memory to intrinsic noise in a transcriptional positive feedback system. Without noise, the system could create two stable steady states and function as a memory module. Memory robustness index and mean first-passage time were used to quantify the robustness of memory. Large cell size and strong cooperativity in binding enhanced memory storage remarkably. Adding a second positive feedback loop improved persistent memory significantly, whereas including a negative one destabilized memory storage. These are consistent with experimental observations. We interpret why positive feedback loops are actively involved in epigenetic memory from a dynamical systems perspective.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Cheng Z,Liu F,Zhang XP,Wang Wdoi
10.1016/j.febslet.2008.10.005subject
Has Abstractpub_date
2008-11-12 00:00:00pages
3776-82issue
27eissn
0014-5793issn
1873-3468pii
S0014-5793(08)00822-3journal_volume
582pub_type
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