Abstract:
:Formation of tubulin/Na(+),K(+)-ATPase (NKA) complex in erythrocytes of hypertensive subjects results in a 50% reduction in NKA activity. We demonstrate here that detyrosinated tubulin, which is increased in hypertensive erythrocytes membranes, enhances the inhibitory effect of acetylated tubulin on NKA activity. Moreover, we report a reduced content and activity of the enzyme tubulin tyrosine ligase in erythrocytes of hypertensive subjects. Such alterations are related to changes in erythrocyte deformability. Our findings indicate that the detyrosination/tyrosination cycle of tubulin is important in regulation of NKA activity, and that abnormalities in this cycle are involved in hypertension development.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Amaiden MR,Santander VS,Monesterolo NE,Nigra AD,Rivelli JF,Campetelli AN,Pie J,Casale CHdoi
10.1016/j.febslet.2014.12.022subject
Has Abstractpub_date
2015-01-30 00:00:00pages
364-73issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(14)00902-8journal_volume
589pub_type
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