Abstract:
:The effect of the inositol phospholipid-binding antibiotic neomycin was studied on high-affinity GTPase in human platelet membranes. At low concentrations (up to 1 mM), neomycin by itself stimulated a high-affinity GTPase. This GTPase stimulation was additive with that caused by the hormonal factors, prostaglandin E1 and epinephrine, but not with thrombin. At concentrations higher than 1 mM, neomycin reduced control GTPase activity and eliminated the stimulation caused by thrombin. The data suggest that neomycin by a presently unknown mechanism can regulate activity states of signal transducing GTP-binding proteins.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Herrmann E,Jakobs KHdoi
10.1016/0014-5793(88)80795-6subject
Has Abstractpub_date
1988-02-29 00:00:00pages
49-53issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(88)80795-6journal_volume
229pub_type
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