Stimulation and inhibition of human platelet membrane high-affinity GTPase by neomycin.

Abstract:

:The effect of the inositol phospholipid-binding antibiotic neomycin was studied on high-affinity GTPase in human platelet membranes. At low concentrations (up to 1 mM), neomycin by itself stimulated a high-affinity GTPase. This GTPase stimulation was additive with that caused by the hormonal factors, prostaglandin E1 and epinephrine, but not with thrombin. At concentrations higher than 1 mM, neomycin reduced control GTPase activity and eliminated the stimulation caused by thrombin. The data suggest that neomycin by a presently unknown mechanism can regulate activity states of signal transducing GTP-binding proteins.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Herrmann E,Jakobs KH

doi

10.1016/0014-5793(88)80795-6

subject

Has Abstract

pub_date

1988-02-29 00:00:00

pages

49-53

issue

1

eissn

0014-5793

issn

1873-3468

pii

0014-5793(88)80795-6

journal_volume

229

pub_type

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