Abstract:
:Apolipoprotein E (apoE) is predominantly synthesized by astrocytes in the brain. In this study, we investigated the role of apoE in astrocyte apoptosis. We demonstrated that apoE protects astrocytes from hypoxia-induced apoptosis in a dose-dependent manner. Glutamate release from astrocytic cultures is significantly lower from WT mice than from apoE knockout mice. Furthermore, the protective effect of apoE is mimicked by an NMDA receptor antagonist, MK-801. Finally, the apoE activator T0901317 significantly reduced the effect of glutamate-induced apoptosis of astrocytes. These results suggest that apoE protects astrocytes from hypoxia-induced apoptosis associated to NMDA receptor activation. Approaches that elevate apoE secretion in astrocytes might provide a novel strategy in the protection of neuronal ischemic injury.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Zhou S,Wu H,Zeng C,Xiong X,Tang S,Tang Z,Sun Xdoi
10.1016/j.febslet.2012.12.003subject
Has Abstractpub_date
2013-01-16 00:00:00pages
254-8issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(12)00908-8journal_volume
587pub_type
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