Abstract:
:We investigated the signaling pathways participating in hyperosmotic regulation of the human taurine transporter (TAUT) by using specific inhibitors of various intracellular signaling molecules. Among them, the specific inhibitor of calcium/calmodulin-dependent protein kinase II (Ca(2+)/CaM kinase II) completely repressed the hyperosmotic regulation of TAUT. The osmosensitive upregulation of TAUT was also significantly inhibited by calmodulin antagonists and calcium-chelators. The increased expression level of TAUT mRNA by hypertonicity was repressed by the specific Ca(2+)/CaM kinase II inhibitor. The activated form of Ca(2+)/CaM kinase II protein could only be detected in Caco-2 cells under hypertonic conditions.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Satsu H,Manabe M,Shimizu Mdoi
10.1016/j.febslet.2004.05.062keywords:
subject
Has Abstractpub_date
2004-07-02 00:00:00pages
123-8issue
1-3eissn
0014-5793issn
1873-3468pii
S0014579304006738journal_volume
569pub_type
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