Abstract:
:Despite significant increases in circulating concentrations of lipid fuels (triacylglycerol, non-esterified fatty acids (NEFA) and ketone bodies) in late-pregnant rats sampled in the fed (absorptive) state, cardiac and skeletal muscle active pyruvate dehydrogenase (PDHa) activities remained comparable with those observed in fed, age-matched virgin controls. Cardiac PDHa activity was suppressed in response to acute (6 h) starvation in late-pregnant (as well as virgin) rats: this inactivation was opposed by inhibition of mitochondrial long-chain FA oxidation. Starvation (6 h) also led to PDH inactivation in skeletal muscles of late-pregnant, but not virgin, rats. Starvation for 24 h led to further suppression of cardiac PDHa activity and was associated with significant increases in PDH kinase activities in both virgin and late-pregnant rats. Late pregnancy did not itself influence cardiac PDH kinase activity.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Sugden MC,Holness MJdoi
10.1016/0014-5793(93)80091-8subject
Has Abstractpub_date
1993-04-26 00:00:00pages
121-6issue
2-3eissn
0014-5793issn
1873-3468pii
0014-5793(93)80091-8journal_volume
321pub_type
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