Abstract:
:Hormone-sensitive lipase (HSL) is responsible for the neutral cholesterol ester hydrolase activity in macrophages. Incubation of intact WEHI macrophages or mouse peritoneal macrophages leads to phosphorylation of HSL, which is increased by incubation with either dibutyryl cyclic AMP and 3-isobutyl-1-methylxanthine or okadaic acid. Correspondingly, these agents also activate neutral cholesterol ester hydrolase activity in intact WEHI cells. Regulation of mobilisation of esterified cholesterol in macrophages may be of antiatherogenic value, which this model system now allows us to investigate further.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Small CA,Rogers MP,Goodacre JA,Yeaman SJdoi
10.1016/0014-5793(91)80179-7subject
Has Abstractpub_date
1991-02-25 00:00:00pages
323-6issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(91)80179-7journal_volume
279pub_type
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