Abstract:
:Adrenomedullin (ADM) functions as a survival factor against hypoxic cell death. However, molecular mechanisms underlying the cell survival pathway remain largely unknown. In this report, we showed that ADM suppressed reactive oxygen species (ROS) increase by inhibiting reduction of glutathione (GSH) level in hypoxia/reoxygenation (H/R) injury, and increased the activities of glutathione peroxidase and reductase. In addition, ADM maintained total and active reduced thioredoxin (Trx) levels against H/R. We also found that ADM blocked nuclear translocation of Trx induced by H/R. The results of the present study show that ADM regulates cellular ROS levels via the GSH and Trx system.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kim SM,Kim JY,Lee S,Park JHdoi
10.1016/j.febslet.2009.11.063subject
Has Abstractpub_date
2010-01-04 00:00:00pages
213-8issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(09)00976-4journal_volume
584pub_type
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