Abstract:
:Trypanosomes are unicellular parasites and like all decent parasites, they try to obtain from the host as much material as possible, including lipids. However, the needs of a parasite are not always the same as those of the host, and therefore, mostly, some biosynthetic work still has to be done by the parasite itself. Very often at least modifications of the lipid components that are acquired from the host have to be made. Furthermore, next to the lipids Trypanosoma brucei indeed obtains from the host, some other lipid components have to be synthesized de novo. Especially the processes where the metabolism of T. brucei differs from that of the host, will be discussed, as at least some of them are excellent targets for the development of urgently needed new chemotherapeutics.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
van Hellemond JJ,Tielens AGdoi
10.1016/j.febslet.2006.07.056subject
Has Abstractpub_date
2006-10-09 00:00:00pages
5552-8issue
23eissn
0014-5793issn
1873-3468pii
S0014-5793(06)00911-2journal_volume
580pub_type
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