Abstract:
:Heme is degraded by heme oxygenase to form iron, carbon monoxide (CO), and biliverdin. However, information about the catabolism of heme in erythroid cells is limited. In this study, we showed the production and export of bilirubin in murine erythroleukemia (MEL) cells. The production of bilirubin by MEL cells was enhanced when heme synthesis was induced. When mouse bone marrow cells were induced with erythropoietin to differentiate into erythroid cells, the synthesis of bilirubin increased. The expression of β-globin was enhanced by CO at the transcriptional level. These results indicate that constant production of CO from heme regulates erythropoiesis.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Mu A,Li M,Tanaka M,Adachi Y,Tai TT,Liem PH,Izawa S,Furuyama K,Taketani Sdoi
10.1002/1873-3468.12178subject
Has Abstractpub_date
2016-05-01 00:00:00pages
1447-54issue
10eissn
0014-5793issn
1873-3468journal_volume
590pub_type
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