Abstract:
:We used a xenograft model to investigate whether the aryl hydrocarbon receptor deletion construct CDelta553 suppresses tumor growth. HeLa cells that were infected with CDelta553 expressing adenovirus (Ad553) formed very small tumors whereas the control adenovirus-infected cells formed large tumors at day 15. CDelta553 inhibited the formation of the HIF-1 DNA complex and suppressed the induction of the HIF-1alpha target proteins CAIX and GLUT1. The Ad553 tumors had less HIF-1 function since they showed reduced microvessel formation and lesser amounts of HIF-1alpha, Arnt, phospho-Akt, CAIX, and GLUT1. Proteasome-mediated Arnt degradation was enhanced in Ad553-infected HeLa cells and tumors.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Wang D,Faridi JS,Li Y,Chan WKdoi
10.1016/j.febslet.2009.08.013subject
Has Abstractpub_date
2009-09-17 00:00:00pages
3039-44issue
18eissn
0014-5793issn
1873-3468pii
S0014-5793(09)00630-9journal_volume
583pub_type
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