Abstract:
:In rat brain astroglia-enriched cultures long-term treatment with interleukin-1beta induces NO release and stimulation of soluble guanylyl cyclase. The cGMP formed is recovered in the extracellular medium but not in the cell monolayer. The interleukin-1beta effect is mediated by type I receptor and potentiated by interferon-gamma. In cells treated with bacterial endotoxin a larger NO-dependent cGMP accumulation occurs only intracellularly, however a significant cGMP egression is observed when cells are co-treated with interleukin-1beta. The non-selective anion transport inhibitors probenecid and verapamil block cGMP efflux, indicating that interleukin-1beta stimulates a cGMP transporter.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Pedraza CE,Baltrons MA,García Adoi
10.1016/s0014-5793(01)03003-4keywords:
subject
Has Abstractpub_date
2001-11-02 00:00:00pages
303-6issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(01)03003-4journal_volume
507pub_type
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