Abstract:
:We have previously shown that unsaturated phosphatidylserines inhibit mitogen-induced T cell activation. We now report that the inhibitory action requires a protein present in bovine and human serum. Partial purification and phospholipase assay show that this protein has phospholipase A activity on phosphatidylserine but not phosphatidylethanolamine, phosphatidylcholine and phosphatidylinositol. In short incubations (1-3 h)2-acyl lysophosphatidylserine is produced but in longer incubations the cis-unsaturated fatty acid is also released. Experiments on peripheral blood mononuclear cells indicate that the unsaturated fatty acid becomes the main responsible for the PS-induced inhibition and that 2-acyl lysophosphatidylserine enhances the inhibitory effect of fatty acid.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Bellini F,Bruni Adoi
10.1016/0014-5793(93)81724-esubject
Has Abstractpub_date
1993-01-18 00:00:00pages
1-4issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(93)81724-Ejournal_volume
316pub_type
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