Abstract:
:Amylin, a 37 amino acid product of pancreatic beta-cells, inhibits insulin-stimulated radioglucose incorporation into muscle glycogen. In the current study, we exercised rats and then prelabelled the glycogen pool by infusing [3-3H]glucose along with glucose and insulin. Subsequent amylin administration increased the rate of appearance of tritiated water 6.4-fold, consistent with stimulation of glycogenolysis and passage of the released moieties through the hexose --> triose step of glycolysis. Further, there was an increase in plasma [3-3H]glucose after amylin, consistent with the release of free glucose previously sequestered in muscle glycogen. Calcitonin gene-related peptide (8-37), an amylin antagonist, prevented these actions.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Young AA,Carlo P,Smith P,Wolfe-Lopez D,Pittner R,Wang MW,Rink Tdoi
10.1016/0014-5793(93)80702-vsubject
Has Abstractpub_date
1993-11-22 00:00:00pages
317-21issue
3eissn
0014-5793issn
1873-3468pii
0014-5793(93)80702-Vjournal_volume
334pub_type
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