Evidence for release of free glucose from muscle during amylin-induced glycogenolysis in rats.

Abstract:

:Amylin, a 37 amino acid product of pancreatic beta-cells, inhibits insulin-stimulated radioglucose incorporation into muscle glycogen. In the current study, we exercised rats and then prelabelled the glycogen pool by infusing [3-3H]glucose along with glucose and insulin. Subsequent amylin administration increased the rate of appearance of tritiated water 6.4-fold, consistent with stimulation of glycogenolysis and passage of the released moieties through the hexose --> triose step of glycolysis. Further, there was an increase in plasma [3-3H]glucose after amylin, consistent with the release of free glucose previously sequestered in muscle glycogen. Calcitonin gene-related peptide (8-37), an amylin antagonist, prevented these actions.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Young AA,Carlo P,Smith P,Wolfe-Lopez D,Pittner R,Wang MW,Rink T

doi

10.1016/0014-5793(93)80702-v

subject

Has Abstract

pub_date

1993-11-22 00:00:00

pages

317-21

issue

3

eissn

0014-5793

issn

1873-3468

pii

0014-5793(93)80702-V

journal_volume

334

pub_type

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