Antioxidant properties of omeprazole.


:Potential antioxidant properties of therapeutically achievable concentrations of the protonated, active form of omeprazole (OM) were investigated in vitro at specific acidic pH values to mimic intragastric conditions in the clinical setting. We found that OM is a powerful scavenger of hypochlorous acid (HOCl) even at a drug concentration of 10 microM at pH 5.3 or 3.5. This effect is also evident in the presence of the physiological HOCl scavenger ascorbate. Moreover, 10 and 50 microM OM inhibit significantly both iron- and copper-driven oxidant damage at pH 5.3 and 3.5, respectively. Since oxidative stress is involved the gastric injury of peptic ulcer and gastritis, it may be hypothesized that some therapeutical effects of OM could also be related to its antioxidant properties.




FEBS letters


Lapenna D,de Gioia S,Ciofani G,Festi D,Cuccurullo F




Has Abstract


1996-03-11 00:00:00












  • The nucleotide sequence of the amiE gene of Pseudomonas aeruginosa.

    abstract::The nucleotide sequence of the amiE gene, encoding the aliphatic amidase of Pseudomonas aeruginosa, has been determined. The sequence of 1038 nucleotides shows a strong bias in favour of codons with G or C in the third position, and only 44 different codons are utilised. ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Brammar WJ,Charles IG,Matfield M,Liu CP,Drew RE,Clarke PH

    更新日期:1987-05-11 00:00:00

  • Functional characterization of the promoter region of the mouse protein kinase C gamma gene.

    abstract::Promoter activity of protein kinase C (PKC) gamma gene was analysed by chloramphenicol acetyltransferase (CAT) assay using extracts from the cells transfected with various fusion constructs containing the 5'-flanking region of the mouse PKC gamma gene and CAT gene. Transient expression experiments in PC12 cells reveal...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Takanaga H,Mukai H,Shimakawa M,Konishi H,Kikkawa U,Koizumi T,Ono Y

    更新日期:1995-07-17 00:00:00

  • Catalytic domain of MMP20 (Enamelysin) - the NMR structure of a new matrix metalloproteinase.

    abstract::The solution structure of the catalytic domain of MMP-20, a member of the matrix metalloproteinases family not yet structurally characterized, complexed with N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid (NNGH), is here reported and compared with other MMPs-NNGH adducts. The backbone dynamic has been ch...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Arendt Y,Banci L,Bertini I,Cantini F,Cozzi R,Del Conte R,Gonnelli L

    更新日期:2007-10-02 00:00:00

  • c-Jun/AP-1 transcription factor regulates laminin-1-induced neurite outgrowth in human bone marrow mesenchymal stem cells: role of multiple signaling pathways.

    abstract::In this study, we demonstrated that laminin-1 (LM-1) induces neurite outgrowth and enhances the expression of neurofilament-L and MAP2 in human bone marrow mesenchymal stem cells (MSCs). The c-Jun transcription factor was strongly activated by LM-1 during neurite induction. Suppression of c-Jun inhibited the expressio...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Mruthyunjaya S,Rumma M,Ravibhushan G,Anjali S,Padma S

    更新日期:2011-06-23 00:00:00

  • Regulation of tau exon 10 splicing by a double stem-loop structure in mouse intron 10.

    abstract::Tau exon 10 (E10) splicing is a crucial event in its developmental change of tau isoform and tauopathy. To investigate the splicing mechanism, we isolated and compared mouse tau genomic sequence with human sequence. We identified a new element in mouse intron 10 (I10) to suppress E10 splicing, which was located just a...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Yamashita T,Tomiyama T,Li Q,Numata H,Mori H

    更新日期:2005-01-03 00:00:00

  • The role of immune semaphorins in multiple sclerosis.

    abstract::The nervous and immune systems have similar functional characteristics. Both have an intricate network of synaptic connections and an exquisite communication system that enable intercellular signal transduction. Although semaphorins were originally identified as guidance cues in neural development, accumulating eviden...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Okuno T,Nakatsuji Y,Kumanogoh A

    更新日期:2011-12-01 00:00:00

  • Mechanical stimulation induces Ca2+i transients and membrane depolarization in cultured endothelial cells. Effects on Ca2+i in co-perfused smooth muscle cells.

    abstract::Cytosolic Ca2+ concentration and membrane potential were monitored in individual cultured endothelial cells mechanically stimulated with a micropipette attached to the stage of a microscope. Both dimpling and poking of endothelial cells resulted in Ca2+i transients (from 63 +/- 12 to 397 +/- 52 nM, characterized by a ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Goligorsky MS

    更新日期:1988-11-21 00:00:00

  • Vav, a GDP/GTP nucleotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation.

    abstract::Vav functions as a specific GDP/GTP nucleotide exchange factor which is regulated by tyrosine phosphorylation in the hematopoietic system. Loss of the amino-terminus sequences of Vav was sufficient to control its transforming potential and its function in T cells. We report here the identification of the hematopoietic...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Groysman M,Russek CS,Katzav S

    更新日期:2000-02-04 00:00:00

  • Enhanced suicide gene therapy by chimeric tumor-specific promoter based on HSF1 transcriptional regulation.

    abstract::Two tandem cassettes, one containing the telomerase reverse transcriptase gene (hTERT) promoter upstream of a constitutively activated form of heat shock transcription factor 1 (cHSF1) and followed by the other containing the heat shock protein 70B (hsp70B) promoter (HSE) upstream of the cytosine deaminase (CD) gene, ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Wang J,Yao M,Zhang Z,Gu J,Zhang Y,Li B,Sun L,Liu X

    更新日期:2003-07-10 00:00:00

  • Translation arrest as a protein quality control system for aberrant translation of the 3'-UTR in mammalian cells.

    abstract::Read-through or mutations of a stop codon resulting in translation of the 3'-UTR produce potentially toxic C-terminally extended proteins. However, quality control mechanisms for such proteins are poorly understood in mammalian cells. Here, a comprehensive analysis of the 3'-UTRs of genes associated with hereditary di...

    journal_title:FEBS letters

    pub_type: 社论


    authors: Hashimoto S,Nobuta R,Izawa T,Inada T

    更新日期:2019-04-01 00:00:00

  • Aluminum inhibits proteolytic degradation of amyloid beta peptide by cathepsin D: a potential link between aluminum accumulation and neuritic plaque deposition.

    abstract::Neuritic plaques are the key pathological feature of Alzheimer's disease, and amyloid beta (Abeta) peptides are major component of these plaques. In this study, we demonstrated the influence of aluminum (Al) on the Abeta peptide degradation by cathepsin D. Al did not directly affect the cathepsin D activity using smal...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Sakamoto T,Saito H,Ishii K,Takahashi H,Tanabe S,Ogasawara Y

    更新日期:2006-12-11 00:00:00

  • Purification and characterization of phospholipase A2 inhibitory proteins from pig thyroid gland.

    abstract::A 32 kDa phospholipase A2 inhibitory protein was isolated from pig thyroid gland after calcium precipitation and fast protein liquid anion-exchange chromatography. SDS-polyacrylamide gel electrophoresis revealed the purity of the protein. The protein activity was assessed by the inhibition of pancreatic phospholipase ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Antonicelli F,Rothhut B,Martiny L,Aguie-Aguie G,Lambert B,Bellon G,Russo-Marie F,Jacquemin C,Haye B

    更新日期:1988-08-01 00:00:00

  • Footprinting of DNA secondary structure by high-intensity (laser) ultraviolet irradiation.

    abstract::The action of high-intensity ultraviolet pulse laser radiation on a 161 bp fragment of pBR 322 DNA (EcoRI-MspI fragment) was studied. At doses up to 5 X 10(18) photons/cm2 the N-glycosidic bond splitting is negligible. The action of hot piperidine on irradiated DNA leads to chain splitting at the residues, modified vi...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Budowsky EI,Kovalsky OI,Yakovlev DYu,Simukova NA,Rubin LB

    更新日期:1985-08-19 00:00:00

  • Selective control of cytosolic glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase mRNA stability by selenium supply.

    abstract::Selenium depletion of H4 hepatoma cells reduced cytosolic glutathione peroxidase (cGSH-Px) mRNA abundance but had no effect on phospholipid hydroperoxide glutathione peroxidase (PHGSH-Px) mRNA abundance. Actinomycin D chase experiments showed that selenium depletion had no effect on the stability of PHGSH-Px mRNA but ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Bermano G,Arthur JR,Hesketh JE

    更新日期:1996-06-03 00:00:00

  • Intrinsic uncoupling of cytochrome c oxidase may cause the maternally inherited mitochondrial diseases MELAS and LHON.

    abstract::Mutations in the human mtDNA gene encoding subunit III of cytochrome c oxidase (CO) have been reported to cause MELAS and LHON. Poracoccus denitrificans cells expressing substitutions homologous to these MELAS- and LHON-causing mutations had lower growth yield than wild type cells and lower efficiency of proton pumpin...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Mather MW,Rottenberg H

    更新日期:1998-08-14 00:00:00

  • Stromal and thylakoid-bound ascorbate peroxidases are produced by alternative splicing in pumpkin.

    abstract::A cDNA encoding stromal ascorbate peroxidase (sAPX) was isolated using poly(A)+ RNA of pumpkin cotyledons by RT-PCR. The cDNA encodes a polypeptide with 372 amino acids and shares complete sequence identity with pumpkin thylakoid-bound ascorbate peroxidase (tAPX), except for the deletion of a putative membrane spannin...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Mano S,Yamaguchi K,Hayashi M,Nishimura M

    更新日期:1997-08-11 00:00:00

  • Expression of serotonin receptor mRNAs in blood vessels.

    abstract::Using RT-PCR we distinguished mRNAs for all known G-protein coupled serotonin receptors expressed in various rat and porcine blood vessels. Nearly all vessels expressed 5HT1D beta, 5-HT2A, 5-HT2B, 5-HT4, and 5-HT7 receptor mRNA to different extents. New splice variants of the porcine 5-HT4 receptor were observed. Simi...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Ullmer C,Schmuck K,Kalkman HO,Lübbert H

    更新日期:1995-08-21 00:00:00

  • Creutzfeldt-Jakob infection increases adenylate cyclase activity in specific regions of guinea pig brain.

    abstract::Creutzfeldt-Jakob disease is a slow, infectious, progressive neurological disorder which results in human dementia. Synaptic membranes from various brain regions of guinea pigs infected with Creutzfeldt-Jakob disease show increased guanyl nucleotide- or 5-hydroxytryptamine-mediated activation of adenylate cyclase. Thi...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Rasenick MM,Valley S,Manuelidis EE,Manuelidis L

    更新日期:1986-03-17 00:00:00

  • Identification of putative calcium channels in skeletal muscle microsomes.

    abstract::Saturable binding sites for the labelled calcium antagonist (+/-)[3H]nimodipine were found in guinea-pig hind limb skeletal muscle homogenates. Binding sites were enriched in a microsomal pellet by differential centrifugation of the homogenate. [3H]Nimodipine binding (Kd = 1.5 +/- 0.03 nM, Bmax = 2.1 +/- 0.25 pmol/pro...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Ferry DR,Glossmann H

    更新日期:1982-11-08 00:00:00

  • Site-specific mutagenesis of the reaction centre from Rhodobacter sphaeroides studied by Fourier transform Raman spectroscopy: mutations at tyrosine M210 do not affect the electronic structure of the primary donor.

    abstract::The effects of mutation of residue tyrosine M210 on the primary donor bacteriochlorophylls have been investigated by near infrared FT-Raman spectroscopy in reaction centres purified from an antenna-deficient strain of Rhodobacter sphaeroides. We find that mutation at the M210 position does not significantly perturb th...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Jones MR,Heer-Dawson M,Mattioli TA,Hunter CN,Robert B

    更新日期:1994-02-14 00:00:00

  • Na(+)-dependent high affinity uptake of L-glutamate in primary cultures of human fibroblasts isolated from three different types of tissue.

    abstract::Cultured human fibroblasts isolated from embryonic muscle, skin and peripheral nerve tissues were found to accumulate [3H]L-glutamate by a Na(+)-dependent uptake process strongly inhibited by several glutamate/aspartate analogues including D- and L-aspartate, D- and L-threo-3-hydroxyaspartate and L-trans-pyrrolidine-2...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Balcar VJ,Shen J,Bao S,King NJ

    更新日期:1994-02-14 00:00:00

  • Potassium channels.

    abstract::The atomic structures of K+ channels have added a new dimension to our understanding of K+ channel function. I will briefly review how structures have influenced our views on ion conduction, gating of the pore, and voltage sensing. ...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: MacKinnon R

    更新日期:2003-11-27 00:00:00

  • RNase L facilitates the repair of DNA double-strand breaks through the nonhomologous end-joining pathway.

    abstract::RNA molecules have been found to play important roles in DNA double-strand break (DSB) repair, but the exact underlying mechanism remains unclear. Here, we aimed to clarify the function of RNase L, an important ribonuclease in the immune system of vertebrates, in DSB repair. Knockdown of RNase L reduces cell survival ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Zhong Y,Pan B,Zhu J,Fu H,Zheng X

    更新日期:2019-06-01 00:00:00

  • Structural and functional characterization of the bacterial translocation inhibitor GE82832.

    abstract::The structure of GE82832, a translocation inhibitor produced by a soil microorganism, is shown to be highly related to that of dityromycin, a bicyclodecadepsipeptide antibiotic discovered long ago whose characterization had never been pursued beyond its structural elucidation. GE82832 and dityromycin were shown to int...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Brandi L,Maffioli S,Donadio S,Quaglia F,Sette M,Milón P,Gualerzi CO,Fabbretti A

    更新日期:2012-09-21 00:00:00

  • Biphasic effect of insulin on beta cell apoptosis depending on glucose deprivation.

    abstract::Insulin resistant states are associated with an increase in the beta cell mass and also high levels of circulating insulin. Ultimately the beta cells undergo a failure that leads to diabetes. At this stage, a question arises if those persistent high levels of circulating insulin may contribute to beta cell damage. To ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Guillen C,Bartolomé A,Nevado C,Benito M

    更新日期:2008-11-26 00:00:00

  • Molecular dynamics simulation of four-alpha-helix bundles that bind the anesthetic halothane.

    abstract::The mutation of a single leucine residue (L38) to methionine (M) is known experimentally to significantly increase the affinity of the synthetic four-alpha-helix bundle (Aalpha(2))(2) for the anesthetic halothane. We present a molecular dynamics study of the mutant (Aalpha(2)-L38M)(2) peptide, which consists of a dime...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Davies LA,Zhong Q,Klein ML,Scharf D

    更新日期:2000-07-28 00:00:00

  • Dependence of rat liver CMP-N-acetylneuraminate:GM1 sialyltransferase (SAT IV) activity on the ceramide composition of GM1 ganglioside.

    abstract::The dependence of CMP-N-acetylneuraminate:GM1 sialyltransferase (SAT IV) activity of rat liver Golgi apparatus on GM1 ganglioside ceramide composition was evaluated. SAT IV activity was assayed on GM1 molecular species carrying homogeneous ceramide moieties containing long chain bases of different length (18 or 20 C a...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Pitto M,Palestini P,Masserini M

    更新日期:1996-04-01 00:00:00

  • Detection of the optical bands of molybdenum(V) in DMSO reductase (Rhodobacter capsulatus) by low-temperature MCD spectroscopy.

    abstract::Dimethylsulphoxide (DMSO) reductase from R. capsulatus contains a molybdenum-pterin cofactor at its active site. As prepared the molybdenum is in the 6+ oxidation state, devoid of EPR signals. Stepwise reduction generates an EPR signal characteristic of Mo(V) having hyperfine coupling to a single proton and integratin...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Benson N,Farrar JA,McEwan AG,Thomson AJ

    更新日期:1992-07-28 00:00:00

  • Stopped-flow spectrophotometry monitoring the initial processes of platelet activation by platelet-activating factor.

    abstract::The initial processes of platelet activation by platelet-activating factor (PAF) were observed by stopped-flow light scattering and fluorometry. The binding of PAF to rabbit platelets did not change the membrane fluidity, though it caused the removal of calcium from internal stores and induced concomitantly platelet s...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Ohga Y,Nakanishi M

    更新日期:1986-10-20 00:00:00

  • NMR analysis of in vitro-synthesized proteins without purification: a high-throughput approach.

    abstract::A cell-free protein expression system was established that provides protein samples of adequate concentration and purity for direct NMR analysis. The Escherichia coli peptidyl-prolyl cis-trans isomerase PpiB was expressed in this system with dual amino acid-selective isotope labeling to identify the NMR signal from th...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Guignard L,Ozawa K,Pursglove SE,Otting G,Dixon NE

    更新日期:2002-07-31 00:00:00