Antioxidant properties of omeprazole.

Abstract:

:Potential antioxidant properties of therapeutically achievable concentrations of the protonated, active form of omeprazole (OM) were investigated in vitro at specific acidic pH values to mimic intragastric conditions in the clinical setting. We found that OM is a powerful scavenger of hypochlorous acid (HOCl) even at a drug concentration of 10 microM at pH 5.3 or 3.5. This effect is also evident in the presence of the physiological HOCl scavenger ascorbate. Moreover, 10 and 50 microM OM inhibit significantly both iron- and copper-driven oxidant damage at pH 5.3 and 3.5, respectively. Since oxidative stress is involved the gastric injury of peptic ulcer and gastritis, it may be hypothesized that some therapeutical effects of OM could also be related to its antioxidant properties.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Lapenna D,de Gioia S,Ciofani G,Festi D,Cuccurullo F

doi

10.1016/0014-5793(96)00155-x

subject

Has Abstract

pub_date

1996-03-11 00:00:00

pages

189-92

issue

1-2

eissn

0014-5793

issn

1873-3468

journal_volume

382

pub_type

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