Antioxidant properties of omeprazole.


:Potential antioxidant properties of therapeutically achievable concentrations of the protonated, active form of omeprazole (OM) were investigated in vitro at specific acidic pH values to mimic intragastric conditions in the clinical setting. We found that OM is a powerful scavenger of hypochlorous acid (HOCl) even at a drug concentration of 10 microM at pH 5.3 or 3.5. This effect is also evident in the presence of the physiological HOCl scavenger ascorbate. Moreover, 10 and 50 microM OM inhibit significantly both iron- and copper-driven oxidant damage at pH 5.3 and 3.5, respectively. Since oxidative stress is involved the gastric injury of peptic ulcer and gastritis, it may be hypothesized that some therapeutical effects of OM could also be related to its antioxidant properties.




FEBS letters


Lapenna D,de Gioia S,Ciofani G,Festi D,Cuccurullo F




Has Abstract


1996-03-11 00:00:00












  • Interactions of the 26-39 fragment of the cro protein from lambda bacteriophage with nucleic acids.

    abstract::A tetradecapeptide with a sequence identical to residues 26-39 of the cro protein from bacteriophage lambda has been synthesized. This peptide has no secondary structure in an aqueous buffer but adopts an alpha-helical conformation in the presence of 20% hexafluoroisopropanol. The fluorescence of the single tyrosyl re...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Mayer R,Lancelot G,Hélène C

    更新日期:1983-03-21 00:00:00

  • Hypotonic shocks activate rat TRPV4 in yeast in the absence of polyunsaturated fatty acids.

    abstract::Transient-receptor-potential channels (TRPs) underlie the sensing of chemicals, heat, and mechanical force. We expressed the rat TRPV1 and TRPV4 subtypes in yeast and monitored their activities in vivo as Ca(2+) rise using transgenic aequorin. Heat and capsaicin activate TRPV1 but not TRPV4 in yeast. Hypotonic shocks ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Loukin SH,Su Z,Kung C

    更新日期:2009-02-18 00:00:00

  • New series of lipoxins isolated from human eosinophils.

    abstract::Granulocytes from human eosinophilic donors were incubated with arachidonic acid or 15-hydroxyeicosatetraenoic acid (15-HETE) and stimulated with the ionophore A23187. The eicosanoids were extracted with reversed-phase cartridges and subjected to RP-HPLC analysis. When extracts from eosinophil-enriched populations wer...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Steinhilber D,Roth HJ

    更新日期:1989-09-11 00:00:00

  • Effect of N-homocysteinylation on physicochemical and cytotoxic properties of amyloid β-peptide.

    abstract::Abstract Hyperhomocysteinemia has recently been identified as an important risk factor for Alzheimer's disease (AD). One of the potential mechanisms underlying harmful effects of homocysteine (Hcy) is site-specific acylation of proteins at lysine residues by homocysteine thiolactone (HCTL). The accumulation of amyloid...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Khodadadi S,Riazi GH,Ahmadian S,Hoveizi E,Karima O,Aryapour H

    更新日期:2012-01-20 00:00:00

  • Ion channels in autoimmune neurodegeneration.

    abstract::Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. Ionic conductances regulate T cell activation as well as neuronal function and thus have been found to play a crucial ...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Ehling P,Bittner S,Budde T,Wiendl H,Meuth SG

    更新日期:2011-12-01 00:00:00

  • Time-dependent inhibition of porcine kidney trehalase by aminosugars.

    abstract::The inhibitory effects of various nitrogen-containing sugars on porcine kidney trehalase were studied. Validamycin A, validoxylamine A and MDL 25,637 were found to be potent, time-dependent inhibitors of the enzyme in vitro. The validoxylamine A-inhibited enzyme showed slow but reversible reactivation over time (t1/2 ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Salleh HM,Honek JF

    更新日期:1990-03-26 00:00:00

  • Meproadifen enhances activation and desensitization of the acetylcholine receptor-ionic channel complex (AChR): single channel studies.

    abstract::The effects of the quaternary agent meproadifen on ACh-activated channel currents were studied on myoballs cultured from hind limb muscles of neonatal rats. Meproadifen (0.02-0.1 microM) combined with ACh (0.1-0.3 microM) in the patch pipette caused an increase, followed by a decrease, in the frequency of channel open...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Aracava Y,Albuquerque EX

    更新日期:1984-09-03 00:00:00

  • Sphingosine-1-phosphate: signaling inside and out.

    abstract::Ample evidence indicates that sphingosine-1-phosphate (SPP) can serve as an intracellular second messenger regulating calcium mobilization, and cell growth and survival. Moreover, the dynamic balance between levels of the sphingolipid metabolites, ceramide and SPP, and consequent regulation of opposing signaling pathw...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Spiegel S,Milstien S

    更新日期:2000-06-30 00:00:00

  • Amino acid substitutions contributing to α2,6-sialic acid linkage binding specificity of human parainfluenza virus type 3 hemagglutinin-neuraminidase.

    abstract::Human parainfluenza virus type 3 (hPIV3) recognizes both α2,3- and α2,6-linked sialic acids, whereas human parainfluenza virus type 1 (hPIV1) recognizes only α2,3-linked sialic acids. To identify amino acid residues that confer α2,6-linked sialic acid recognition of hPIV3, amino acid residues in or neighboring the sia...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Fukushima K,Takahashi T,Ueyama H,Takaguchi M,Ito S,Oishi K,Minami A,Ishitsubo E,Tokiwa H,Takimoto T,Suzuki T

    更新日期:2015-05-08 00:00:00

  • Tropoelastin binding to fibulins, nidogen-2 and other extracellular matrix proteins.

    abstract::Elastic fibers in vessel walls and other tissues consist of cross-linked tropoelastin in association with several microfibrillar proteins. In order to understand the molecular basis of these structures, we examined the binding of recombinant human tropoelastin to other extracellular matrix ligands in solid phase bindi...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Sasaki T,Göhring W,Miosge N,Abrams WR,Rosenbloom J,Timpl R

    更新日期:1999-10-29 00:00:00

  • Involvement of electrostatic phenomena in phospholamban-induced stimulation of Ca uptake into cardiac sarcoplasmic reticulum.

    abstract::The activity of the Ca-pumping ATPase of cardiac sarcoplasmic reticulum (SR) is controlled by the phosphorylation of the intrinsic regulatory protein phospholamban (PLB), which affects both the apparent Km(Ca) and the Vmax of the transport process. We have investigated the correlation between phosphorylation of PLB an...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Chiesi M,Schwaller R

    更新日期:1989-02-13 00:00:00

  • Primary structure of the major glycans of the N-acetyllactosamine type derived from the human immunoglobulins M from two patients with Waldenström's macroglobulinemia.

    abstract::The carbohydrate chains of the pathological human immunoglobulins M from two patients with Waldenström's macroglobulinemia were released by hydrazinolysis. The N-acetyllactosamine-type glycans were obtained by affinity chromatography on concanavalin A and fractionated by high-voltage paper electrophoresis. The primary...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Cahour A,Debeire P,Hartmann L,Montreuil J,van Halbeek H,Vliegenthart JF

    更新日期:1984-05-21 00:00:00

  • Vav, a GDP/GTP nucleotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation.

    abstract::Vav functions as a specific GDP/GTP nucleotide exchange factor which is regulated by tyrosine phosphorylation in the hematopoietic system. Loss of the amino-terminus sequences of Vav was sufficient to control its transforming potential and its function in T cells. We report here the identification of the hematopoietic...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Groysman M,Russek CS,Katzav S

    更新日期:2000-02-04 00:00:00

  • Site-directed mutagenesis of Lys600 in phosphoenolpyruvate carboxylase of Flaveria trinervia: its roles in catalytic and regulatory functions.

    abstract::Phosphoenolpyruvate carboxylases from various organisms contain two conserved lysine residues. In the C4 dicot Flaveria trinervia, one of these residues is Lys600. Converting this Lys600 to Arg600 or Thr600 mainly increased the Km values and but had minimal effect on the Vmax. The Km for PEP, Mg2+ increased by up to 3...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Gao Y,Woo KC

    更新日期:1995-11-13 00:00:00

  • Two-dimensional gel electrophoresis and FTIR spectroscopy reveal both forms of yeast plasma membrane H(+)-ATPase in activated and basal-level enzyme preparations.

    abstract::Plasma membrane H(+)-ATPase of the yeast Saccharomyces cerevisiae was isolated and purified in its two forms, the activated A-ATPase from glucose-metabolizing cells, and the basal-level B-ATPase from cells with endogenous metabolism only. Using two-dimensional gel electrophoretic analysis, we showed that both enzyme p...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Lapathitis G,Tanfani F,Kotyk A,Bertoli E

    更新日期:2001-09-07 00:00:00

  • Vpu from HIV-1 on an atomic scale: experiments and computer simulations.

    abstract::Vpu is an 81 amino acid protein encoded by HIV-1. Its role is to amplify viral release by two mechanisms: (i) docking to CD4 with the consequence of targeting CD4 for ubiquitine-mediated degradation, and (ii) formation of ion channels to enhance particle release. The intensive research on its in vivo function, combine...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Fischer WB

    更新日期:2003-09-18 00:00:00

  • A novel dimer of a C-type lectin-like heterodimer from the venom of Calloselasma rhodostoma (Malayan pit viper).

    abstract::We have isolated a potent platelet aggregation inducer from the crude venom of Calloselasma rhodostoma (Malayan pit viper), termed rhodoaggretin, with a novel oligomeric structure consisting of a dimer of C-type lectin-like heterodimers. On the basis of its native molecular mass of 66 kDa, and a M(r) of 30 kDa for its...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Wang R,Kong C,Kolatkar P,Chung MC

    更新日期:2001-11-23 00:00:00

  • Putrescine may be a natural stimulator of glucose-6-phosphate dehydrogenase.

    abstract::The possible relationship between pyridoxal phosphate-dependent ornithine decarboxylase (ODC) activity and glucose-6-phosphate dehydrogenase (G6PD) activity has been studied in the osteoblasts of the growth-plate of metatarsals of rats fed a pyridoxine-deficient diet, which caused depressed G6PD levels. The G6PD activ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Dodds RA,Dunham J,Bitensky L,Chayen J

    更新日期:1986-05-26 00:00:00

  • Specificity of novel allosterically trans- and cis-activated connected maxizymes that are designed to suppress BCR-ABL expression.

    abstract::Chronic myelogenous leukemia (CML) is associated with the presence of the Philadelphia chromosome, which is generated by the reciprocal translocation of chromosomes 9 and 22. In the case of L6 (b2a2) mRNA, it is difficult to cleave the abnormal mRNA specifically because the mRNA includes no sequences that can be cleav...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Hamada M,Kuwabara T,Warashina M,Nakayama A,Taira K

    更新日期:1999-11-12 00:00:00

  • Differential activation by fMet-Leu-Phe and phorbol ester of a plasma membrane phosphatidylcholine-specific phospholipase D in human neutrophil.

    abstract::Signal transduction involving phosphatidylcholine hydrolysis has been investigated in human neutrophils (PMN) after in situ generation of [3H]alkylacyl-sn-glycero-3-phosphocholine ([3H]alkylacyl-GPC) by cell incubation with [3H]alkylacetyl-GPC. When PMN were stimulated with the chemotactic peptide N-formyl-Met-Leu-Phe...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Gelas P,Ribbes G,Record M,Terce F,Chap H

    更新日期:1989-07-17 00:00:00

  • DNA-binding proteins of the Whirly family in Arabidopsis thaliana are targeted to the organelles.

    abstract::Arabidopsis thaliana contains three genes with high homology to potato p24 which was described as a member of the Whirly family of nuclear transcriptional activators. Computer-based analysis revealed that all Arabidopsis Whirly (Why) proteins contain targeting sequences for either plastids or mitochondria. The functio...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Krause K,Kilbienski I,Mulisch M,Rödiger A,Schäfer A,Krupinska K

    更新日期:2005-07-04 00:00:00

  • Immunological characterization of microtubule-associated proteins specific for the immature brain.

    abstract::Immunoblotting analysis was used to detect the microtubule-associated proteins present at different stages of rat brain development. Polyclonal antibodies were raised against the two main adult brain microtubule-associated proteins: MAP-2 (300 kDa) and TAU (60-70 kDa). Whatever the stage of development, anti-MAP-2 ser...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Couchie D,Nunez J

    更新日期:1985-09-02 00:00:00

  • Growth control mechanisms in neuronal regeneration.

    abstract::Neurons grow during development and extend long axons to make contact with their targets with the help of an intrinsic program of axonal growth as well as a range of extrinsic cues and a permissive milieu. Injury events in adulthood induce some neuron types to revert to a regenerative state in the peripheral nervous s...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Doron-Mandel E,Fainzilber M,Terenzio M

    更新日期:2015-06-22 00:00:00

  • Investigating the nucleic acid interactions of histone-derived antimicrobial peptides.

    abstract::While many antimicrobial peptides (AMPs) disrupt bacterial membranes, some translocate into bacteria and interfere with intracellular processes. Buforin II and DesHDAP1 are thought to kill bacteria by interacting with nucleic acids. Here, molecular modeling and experimental measurements are used to show that neither n...

    journal_title:FEBS letters

    pub_type: 信件


    authors: Sim S,Wang P,Beyer BN,Cutrona KJ,Radhakrishnan ML,Elmore DE

    更新日期:2017-03-01 00:00:00

  • Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-kappaB pathway inhibition.

    abstract::Anandamide (AEA) exhibits anti-inflammatory effects. However, its role in the periodontal field remains unknown. Here, we found that gingival crevicular fluid contained a detectable level of AEA. The cannabinoid receptors CB1 and CB2 were expressed by human gingival fibroblasts (HGFs), and markedly upregulated under p...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Nakajima Y,Furuichi Y,Biswas KK,Hashiguchi T,Kawahara K,Yamaji K,Uchimura T,Izumi Y,Maruyama I

    更新日期:2006-01-23 00:00:00

  • Laminin alpha1 chain mediated reduction of laminin alpha2 chain deficient muscular dystrophy involves integrin alpha7beta1 and dystroglycan.

    abstract::Transgenically introduced laminin (LN) alpha1 chain prevents muscular dystrophy in LNalpha2 chain deficient mice. We now report increased integrin alpha7Bbeta1D synthesis in dystrophic LNalpha2 chain deficient muscle. Yet, immunofluorescence demonstrated a reduced expression of integrin alpha7B subunit at the sarcolem...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Gawlik KI,Mayer U,Blomberg K,Sonnenberg A,Ekblom P,Durbeej M

    更新日期:2006-03-20 00:00:00

  • Role of glycosylation in hyperphosphorylation of tau in Alzheimer's disease.

    abstract::In Alzheimer's disease (AD) brain, microtubule-associated protein tau is abnormally modified by hyperphosphorylation and glycosylation, and is aggregated as neurofibrillary tangles of paired helical filaments. To investigate the role of tau glycosylation in neurofibrillary pathology, we isolated various pools of tau p...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Liu F,Zaidi T,Iqbal K,Grundke-Iqbal I,Merkle RK,Gong CX

    更新日期:2002-02-13 00:00:00

  • Differential regulation of the STARD1 subfamily of START lipid trafficking proteins in human macrophages.

    abstract::The STARD1 subfamily of 'START' lipid trafficking proteins can reduce macrophage lipid content and inflammatory status (STARD1; StAR), and traffic cholesterol from endosomes (STARD3/MLN64). During macrophage differentiation, STARD1 mRNA and protein increase with sterol content, while the reverse is true for STARD3. St...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Borthwick F,Taylor JM,Bartholomew C,Graham A

    更新日期:2009-04-02 00:00:00

  • An Escherichia coli cyoE gene homologue in thermophilic Bacillus PS3 encodes a thermotolerant heme O synthase.

    abstract::The cyoE gene of the Escherichia coli bo-type quinol oxidase operon (cyoABCDE) has been previously shown to encode heme O synthase. To demonstrate a catalytic role of a cyoE homologue (the caaE gene) in the gene cluster for caa3-type cytochrome c oxidase of thermophilic Bacillus PS3, we have carried out genetic comple...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Saiki K,Mogi T,Ishizuka M,Anraku Y

    更新日期:1994-09-12 00:00:00

  • New genotypes of TT virus (TTV) and a genotyping assay based on restriction fragment length polymorphism.

    abstract::A phylogenetic analysis, using the open reading frame I sequence of 93 TT viruses (TTV) obtained from various geographical areas, indicated that the virus could be classified into six different genotypes including three hitherto unreported genotypes. The high reliability of the six clusters was confirmed by bootstrap ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Tanaka Y,Mizokami M,Orito E,Ohno T,Nakano T,Kato T,Kato H,Mukaide M,Park YM,Kim BS,Ueda R

    更新日期:1998-10-23 00:00:00