Characterization of a scyllo-inositol-containing sialyloligosaccharide from normal human urine.

abstract：:Mitochondria continually fuse and divide to dynamically adapt to changes in metabolism and stress. Mitochondrial dynamics are also required for mitochondrial DNA (mtDNA) integrity; however, the underlying reason is not known. In this study, we examined the link between mitochondrial fusion and mtDNA maintenance in Sch...

journal_title：FEBS letters

authors： Delerue T,Khosrobakhsh F,Daloyau M,Emorine LJ,Dedieu A,Herbert CJ,Bonnefoy N,Arnauné-Pelloquin L,Belenguer P

更新日期：2016-10-01 00:00:00

abstract：:Chaperone-mediated autophagy (CMA) is a lysosomal pathway that participates in the degradation of cytosolic proteins. CMA is activated by starvation and in response to stressors that result in protein damage. The selectivity intrinsic to CMA allows for removal of damaged proteins without disturbing nearby functional o...

journal_title：FEBS letters

authors： Kon M,Cuervo AM

更新日期：2010-04-02 00:00:00

abstract：:Osteoblasts and adipocytes are believed to share a common progenitor. Peroxisome proliferator-activated receptor gamma (PPARgamma) plays a key role in the switching of these two cell lineages. Here, we demonstrated the differentiation of ES cells into an osteoblastic lineage using siRNA against PPARgamma without the a...

journal_title：FEBS letters

authors： Yamashita A,Takada T,Nemoto K,Yamamoto G,Torii R

更新日期：2006-07-24 00:00:00

abstract：:Aquaporin-4, a predominant water channel in the central nervous system, has two isoforms, M1 and M23, whose transcripts are driven by distinct promoters. Using a reporter assay, we found that a fragment located between exons 0 and 1 of the mouse aquaporin-4 gene, which had been thought to be the promoter for M23, lack...

journal_title：FEBS letters

authors： Abe Y,Goda W,Ikeshima-Kataoka H,Yasui M

更新日期：2017-12-01 00:00:00

abstract：:The known members of inhibitor of growth (ING) gene family are considered as candidate tumor suppressor genes. ING4, a novel member of ING family, is recently reported to interact with tumor suppressor p53, p300 (a major component of histone acetyl transferase complexes), and p65(RelA) subunit of NF-kappaB. In this st...

journal_title：FEBS letters

authors： Zhang X,Xu LS,Wang ZQ,Wang KS,Li N,Cheng ZH,Huang SZ,Wei DZ,Han ZG

更新日期：2004-07-16 00:00:00

abstract：:Using radiolysis with (32)P enriched phosphate as an internal source of ionizing radiation, the formation of hydroperoxo-ferric complex from oxy-ferrous precursor with a high yield was monitored at 77 K in heme oxygenase (HO) by means of optical absorption spectroscopy. Well-resolved absorption spectra (maxima at 421 ...

journal_title：FEBS letters

authors： Denisov IG,Ikeda-Saito M,Yoshida T,Sligar SG

更新日期：2002-12-04 00:00:00

abstract：:Growth of E. coli in the presence of the protonophorous uncoupler pentachlorophenol is shown to strongly enhance levels of cytochrome d, a putative Na(+)-motive oxidase. This effect was found to be arrested by chloramphenicol and stimulated by high Na+ concentration in the growth medium. The induction of cytochrome d ...

journal_title：FEBS letters

authors： Bogachev AV,Murtazina RA,Skulachev VP

更新日期：1993-12-20 00:00:00

abstract：:For almost 30 years, Wnt proteins have been known as key regulators of many developmental decisions, including the formation of the embryonic axes, patterning of the CNS, limb bud outgrowth and segment polarity. However, live cell imaging of active Wnt proteins was rarely reported. Here, we have generated a Wnt2b-EGFP...

journal_title：FEBS letters

authors： Holzer T,Liffers K,Rahm K,Trageser B,Ozbek S,Gradl D

更新日期：2012-06-04 00:00:00

abstract：:We investigated the effect of hydroxyl substituted chalcone (1a) and some chalcone analogues (1b-d) on isolated rat liver mitochondria to gain new insights into the cytotoxic mechanism of these compounds. We observed an inhibitory effect on phosphorylation and the partial uncoupling of compounds 1a and 1d. Increased r...

journal_title：FEBS letters

authors： Guzy J,Vasková-Kubálková J,Rozmer Z,Fodor K,Mareková M,Poskrobová M,Perjési P

更新日期：2010-02-05 00:00:00

abstract：:The peroxisome assembly factor-1 (PAF-1) is reported here to contain the signature subsequence for a ring finger motif in its carboxyl-terminus. This conserved subsequence in PAF-1 may be the key to a gene expression regulatory pathway important in peroxisome biogenesis. ...

journal_title：FEBS letters

authors： Patarca R,Fletcher MA

更新日期：1992-11-02 00:00:00

abstract：:We have isolated cDNA molecules encoding a protein with the characteristic sequence elements that are conserved between the catalytic domains of protein kinases. This protein is apparently a serine/threonine kinase and is most closely related to the amino-terminal half of the ribosomal protein S6 kinase II first chara...

journal_title：FEBS letters

authors： Harmann B,Kilimann MW

更新日期：1990-10-29 00:00:00

abstract：:The human DNA-dependent activator of IFN-regulatory factor (DAI) protein, which activates the innate immune response in response to DNA, contains two tandem Z-DNA binding domains (Zα and Zβ) at the NH(2) terminus. The hZβ(DAI) structure is similar to other Z-DNA binding proteins, although it demonstrates an unusual Z-...

journal_title：FEBS letters

authors： Kim HE,Ahn HC,Lee YM,Lee EH,Seo YJ,Kim YG,Kim KK,Choi BS,Lee JH

更新日期：2011-03-09 00:00:00

abstract：:We have identified an Arabidopsis thaliana cDNA, designated as AtTBP1, encoding a protein with a predicted size of 70.6 kDa that specifically binds to the plant telomeric repeat sequence TTTAGGG. AtTBP1 is present as a single-copy gene in Arabidopsis genome and is expressed ubiquitously in various organs. AtTBP1 has a...

journal_title：FEBS letters

authors： Hwang MG,Chung IK,Kang BG,Cho MH

更新日期：2001-08-10 00:00:00

abstract：:Oncogenic mutations disrupt the regulatory circuits that govern cell function, enabling tumor cells to undergo de-regulated mitogenesis, to resist to pro-apoptotic insults, and to invade through tissue boundaries. Cancer cell biology has played a crucial role in elucidating the signaling mechanisms by which oncogenic ...

journal_title：FEBS letters

authors： Giancotti FG

更新日期：2014-08-19 00:00:00

abstract：:Extracellular laccase (benzenediol: oxygen oxidoreductase EC 1.10.3.2) from the lignin-degrading fungus, Phlebia radiata, was shown to contain a novel combination of electron carriers as its prosthetic groups. In addition to two copper atoms per enzyme molecule, one molecule of PQQ was included as a cofactor. The EPR ...

journal_title：FEBS letters

authors： Karhunen E,Niku-Paavola ML,Viikari L,Haltia T,van der Meer RA,Duine JA

更新日期：1990-07-02 00:00:00

abstract：:1H-NMR spectroscopy has been applied to identify components in the urine of subjects with a deficiency of the enzyme 3-hydroxy-3-methylglutaryl-CoA lyase. One-dimensional spectra of samples from a pair of non-identical twins with this disorder were very similar and are probably diagnostic. The most intense signals wer...

journal_title：FEBS letters

authors： Iles RA,Jago JR,Williams SR,Chalmers RA

更新日期：1986-07-14 00:00:00

abstract：:We report here the first comprehensive comparative NH2-terminal sequence studies of interstitial retinol-binding protein (IRBPs) from nine mammals (including cattle) and one amphibian. This study has revealed that in many species the N-terminus of IRBP includes a 3-6 amino acid extension. IRBP possessing this leader s...

journal_title：FEBS letters

authors： Fong SL,Cook RG,Alvarez RA,Liou GI,Landers RA,Bridges CD

更新日期：1986-09-15 00:00:00

abstract：:This study was performed to prove our hypothesis that the metabolite(s) of polycyclic aromatic hydrocarbons (PAHs) caused the activation or phosphorylation of p53 via DNA damage to suppress the liver X receptor (LXR)-mediated signal transductions as a probably more direct mechanism. We found that LXR-mediated trans-ac...

journal_title：FEBS letters

authors： Iwano S,Shibahara N,Saito T,Kamataki T

更新日期：2006-02-06 00:00:00

abstract：:FITC-labeled LPS from Neisseria meningitidis can be used as a probe to follow the process of LPS incorporation into liposomal membrane and to study its interaction with a bilayer. The incorporation of FITC-LPS into the bilayer was proved by physicochemical methods as well as by liposomal LPS toxicity decrease in actin...

journal_title：FEBS letters

authors： Trubetskoy VS,Koshkina NV,Omel'yanenko VG,L'vov VL,Dmitriev BA,Petrov AB,Torchilin VP

更新日期：1990-08-20 00:00:00

abstract：:Jasmonic acid (JA) has been shown to be a signaling compound which elicits the production of secondary metabolites including phytoalexins in plants. It has been shown that the phytoalexin production is elicited by exogenously applied JA in rice leaves. We now show that this phytoalexin production by exogenously applie...

journal_title：FEBS letters

authors： Tamogami S,Rakwal R,Kodama O

更新日期：1997-07-21 00:00:00

abstract：:We previously identified a benzyloxycarbonyl(Z)-Leu-Leu-Leu-4-methylcoumaryl-7-amide (ZLLL-MCA) degrading activity in proteasome as a candidate for the regulator of neurite outgrowth. As its counterpart, we purified a protein from bovine brain that specifically inhibits the ZLLL-MCA degrading activity in proteasome. T...

journal_title：FEBS letters

authors： Tsubuki S,Saito Y,Kawashima S

更新日期：1994-05-16 00:00:00

abstract：:Oligomeric structures of the four LOV domains in Arabidopsis phototropin1 (phot1) and 2 (phot2) were studied using crosslinking. Both LOV1 domains of phot1 and phot2 form a dimer independently on the light conditions, suggesting that the LOV1 domain can be a stable dimerization site of phot in vivo. In contrast, phot1...

journal_title：FEBS letters

authors： Katsura H,Zikihara K,Okajima K,Yoshihara S,Tokutomi S

更新日期：2009-02-04 00:00:00

abstract：:Cytochrome c oxidase has been isolated from beef heart mitochondria and labeled with the fluorochrome eosin-5-maleimide (EMA) after pretreatment with mersalyl. On SDS-polyacrylamide gels, EMA fluorescence and absorption occurred at a single band corresponding to subunit III. Since only Cys 115 of the two cysteinyl res...

journal_title：FEBS letters

authors： Müller M,Azzi A

更新日期：1985-05-06 00:00:00

abstract：:The concentration of caffeine required to elute wholly single-stranded DNA from benzoylated DEAE-cellulose is proportional to the polynucleotide length. The use of benzoylated DEAE-cellulose chromatography for isolating and sizing single-stranded regions in double-stranded DNA has been examined using a series of hybri...

journal_title：FEBS letters

authors： Norris MD,Stewart BW

更新日期：1988-02-15 00:00:00

abstract：:Using crude membrane preparations of Saccharomyces cerevisiae, we have demonstrated that glucose and glucose analogues which are not efficiently phosphorylated activate the guanine nucleotide-dependent adenylate cyclase in vitro. The activation appears to be mediated by the Ras proteins. Moreover, data are presented i...

journal_title：FEBS letters

authors： Pardo LA,Sánchez LM,Lazo PS,Ramos S

更新日期：1991-09-23 00:00:00

abstract：:Here we summarize evidence for non-equivalence of two structurally similar active sites in transketolase and other thiamine-dependent enzymes. This non-equivalence takes place when the enzymes interact with various ligands (inhibitors, cations, coenzyme and substrates). Data on different strains in the structure of th...

journal_title：FEBS letters

authors： Kovina MV,Kochetov GA

更新日期：1998-11-27 00:00:00

abstract：:Calcium channels derived from sarcoplasmic reticulum of frog skeletal muscle were fused with planar lipid bilayers. Fractional open times displayed two types of calcium dependence: (i) blockable channels showed a bell-shaped calcium dependence with an activation constant of 4.5 microM, a Hill coefficient for activatio...

journal_title：FEBS letters

authors： Bull R,Marengo JJ

更新日期：1993-10-04 00:00:00

abstract：:In mammalian cells, the Bcl-2 and Bcl-x(L) proteins suppress programmed cell death whereas the topographically similar Bax protein accelerates the apoptotic process. Recently published data suggest that expression of the human Bax-alpha gene is lethal for the yeast Saccharomyces cerevisiae and that this toxicity can b...

journal_title：FEBS letters

authors： Greenhalf W,Stephan C,Chaudhuri B

更新日期：1996-02-12 00:00:00

abstract：:A variant form of the heptacosapeptide amide secretin, with C-terminal -Val-Gly-Lys-Arg instead of valine amide, has been isolated from porcine upper intestinal tissue. Unexpectedly, this triacontapeptide exhibited a substantially higher bioactivity than the heptacosapeptide amide. ...

journal_title：FEBS letters

authors： Gafvelin G,Carlquist M,Mutt V

更新日期：1985-05-20 00:00:00

abstract：:Human CBS1 is a methionine sulfoxide reductase of type B (MSRB) as it specifically reduced Met-R-SO in peptides with dithiothreitol or the thioredoxin system as reductants. Mutation C169S in the active site completely abolished enzymatic activity, while mutation W110A only reduced activity and C105S had no effect. Lik...

journal_title：FEBS letters

authors： Jung S,Hansel A,Kasperczyk H,Hoshi T,Heinemann SH

更新日期：2002-09-11 00:00:00