Abstract:
:Oncogenic mutations disrupt the regulatory circuits that govern cell function, enabling tumor cells to undergo de-regulated mitogenesis, to resist to pro-apoptotic insults, and to invade through tissue boundaries. Cancer cell biology has played a crucial role in elucidating the signaling mechanisms by which oncogenic mutations sustain these malignant behaviors and thereby in identifying rational targets for cancer drugs. The efficacy of such targeted therapies illustrate the power of a reductionist approach to the study of cancer.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Giancotti FGdoi
10.1016/j.febslet.2014.02.005subject
Has Abstractpub_date
2014-08-19 00:00:00pages
2558-70issue
16eissn
0014-5793issn
1873-3468pii
S0014-5793(14)00124-0journal_volume
588pub_type
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