Abstract:
:The urokinase receptor (uPAR) on the cell surface plays an important role in extracellular proteolysis, cell migration and adhesion. Soluble uPAR (suPAR) has been recently discovered in plasma, but its origin is unclear. Our results now demonstrate that both unstimulated blood mononuclear and endothelial cells can release suPAR and that the release is enhanced when either mononuclear cells or thrombocytes are cultured together with endothelial cells. Co-culture without cell-cell contacts fails to enhance suPAR release. We also found suPAR fragments, known to be potent inducers of chemotaxis, in co-culture growth medium samples. Taken together, our results suggest that normal plasma suPAR can be produced by endothelial and mononuclear cells and that suPAR release in cell-cell contacts may have a regulatory role in cell adhesion.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Mustjoki S,Sidenius N,Vaheri Adoi
10.1016/s0014-5793(00)02312-7keywords:
subject
Has Abstractpub_date
2000-12-15 00:00:00pages
237-42issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(00)02312-7journal_volume
486pub_type
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