Abstract:
:T-kininogen is known to be an acute-phase reactant as well as a kininogen in rat plasma. Three kinds of cytokines, interleukin-1, tumor necrosis factor and interferon, were assayed for their abilities to stimulate hepatic production of T-kininogen. Of these cytokines, interferon was able to stimulate hepatic production of T-kininogen, but few effects were observed for interleukin-1 and tumor necrosis factor. In addition, the stimulatory effect of interferon was inhibited by tumor necrosis factor. Our data suggest that interferon is a candidate for the leukocyte-derived factor mediating the acute-phase response of T-kininogen.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Itoh N,Yayama K,Okamoto Hdoi
10.1016/0014-5793(88)81134-7subject
Has Abstractpub_date
1988-03-14 00:00:00pages
247-50issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(88)81134-7journal_volume
229pub_type
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