G protein-coupled receptor kinase 2 (GRK2): mechanisms of regulation and physiological functions.

Abstract:

:G protein-coupled receptor kinase 2 (GRK2) plays a key role in determining the rate and extent of G protein-coupled receptor (GPCR) desensitization and resensitization. Recent data indicate that GRK2 activity, subcellular distribution and expression are tightly regulated. The important physiological function of GRK2 as a modulator of the efficacy of GPCR signal transduction systems is exemplified by its relevance in cardiovascular physiopathology as well as by its emerging role in the regulation of chemokine receptors.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Aragay AM,Ruiz-Gómez A,Penela P,Sarnago S,Elorza A,Jiménez-Sainz MC,Mayor F Jr

doi

10.1016/s0014-5793(98)00495-5

subject

Has Abstract

pub_date

1998-06-23 00:00:00

pages

37-40

issue

1-2

eissn

0014-5793

issn

1873-3468

pii

S0014579398004955

journal_volume

430

pub_type

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