Abstract:
:The effects of guanine nucleotides on arachidonic acid (AA) release were studied in intact and saponin-permeabilized human platelets. While GTP[S] itself caused a stimulation of AA release in permeabilized cells, GTP[S], GDP[S], GTP, ATP and other nucleotides inhibited AA release in response to thrombin and other agonists in intact, as well as permeabilized platelets. Inhibition of agonist-stimulated AA release by nucleotides was partially attenuated by addition of ADP, and was abolished by prior stimulation of platelets to discharge the ADP-containing dense granules. These results suggest: (i) that released ADP plays an important contributory role in agonist-stimulated platelet AA release, and (ii) that guanine nucleotides can modulate platelet activation through an extracellular action which is distinct from their effects on G-proteins.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Rehm AG,Wu H,Halenda SPdoi
10.1016/0014-5793(88)80107-8subject
Has Abstractpub_date
1988-07-18 00:00:00pages
316-20issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(88)80107-8journal_volume
234pub_type
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